Comparison of SP263 and 22C3 immunohistochemistry PD-L1 assays for clinical efficacy of adjuvant atezolizumab in non-small cell lung cancer: results from the randomized phase III IMpower010 trial.
J Immunother Cancer
; 11(10)2023 10.
Article
en En
| MEDLINE
| ID: mdl-37903590
ABSTRACT
BACKGROUND:
Tumor samples from the phase III IMpower010 study were used to compare two programmed death-ligand 1 (PD-L1) immunohistochemistry assays (VENTANA SP263 and Dako 22C3) for identification of PD-L1 patient subgroups (negative, positive, low, and high expression) and their predictive value for adjuvant atezolizumab compared with best supportive care (BSC) in resectable early-stage non-small cell lung cancer (NSCLC).METHODS:
PD-L1 expression was assessed by the SP263 assay, which measured the percentage of tumor cells with any membranous PD-L1 staining, and the 22C3 assay, which scored the percentage of viable tumor cells showing partial or complete membranous PD-L1 staining.RESULTS:
When examining the concordance at the PD-L1-positive threshold (SP263 tumor cell (TC)≥1%; 22C3 tumor proportion score (TPS)≥1%), the results were concordant between assays for 83% of the samples. Similarly, at the PD-L1-high cut-off (SP263 TC≥50%; 22C3 TPS≥50%), the results were concordant between assays for 92% of samples. The disease-free survival benefit of atezolizumab over BSC was comparable between assays for PD-L1-positive (TC≥1% by SP263 HR, 0.58 (95% CI 0.40 to 0.85) vs TPS≥1% by 22C3 HR, 0.65 (95% CI 0.45 to 0.95)) and PD-L1-high (TC≥50% by SP263 HR, 0.27 (95% CI 0.14 to 0.53) vs TPS≥50% by 22C3 HR, 0.31 (95% CI 0.16 to 0.60)) subgroups.CONCLUSIONS:
The SP263 and 22C3 assays showed high concordance and a comparable clinical predictive value of atezolizumab at validated PD-L1 thresholds, suggesting that both assays can identify patients with early-stage NSCLC most likely to experience benefit from adjuvant atezolizumab. TRIAL REGISTRATION NUMBER NCT02486718.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
6_ODS3_enfermedades_notrasmisibles
Problema de salud:
6_other_respiratory_diseases
/
6_trachea_bronchus_lung_cancer
Asunto principal:
Carcinoma de Pulmón de Células no Pequeñas
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Carcinoma Pulmonar de Células Pequeñas
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Neoplasias Pulmonares
Límite:
Humans
Idioma:
En
Revista:
J Immunother Cancer
Año:
2023
Tipo del documento:
Article
País de afiliación:
China