Efficacy and safety of factor Xa inhibitors in low body weight patients.
Pharmacotherapy
; 44(2): 131-140, 2024 Feb.
Article
en En
| MEDLINE
| ID: mdl-37926690
ABSTRACT
STUDY OBJECTIVE:
The purpose of this study is to provide evidence for the safety and efficacy of factor Xa inhibitors in patients with a weight ≤60 kg or BMI < 18.5 kg/m2 .DESIGN:
Multicenter, retrospective, cohort study.SETTING:
Twenty-two Ascension Health hospitals. PATIENTS Low-body-weight adult patients (weight ≤ 60 kg or BMI < 18.5 kg/m2 ) receiving treatment for atrial fibrillation or venous thromboembolism. INTERVENTION Factor Xa inhibitors (apixaban or rivaroxaban) or warfarin. MEASUREMENTS AND MAINRESULTS:
This study included 2538 patients between the factor Xa inhibitors (n = 1695) and warfarin (n = 843) groups with a mean weight of 53.5 ± 5.5 kg and BMI of 20.7 ± 3.1 kg/m2 . No significant difference in time to major bleeding was noted after controlling for potential confounders (HR 1.03, 95% CI 0.70-1.53, p = 0.87); similar results were seen following propensity score matching. Thromboembolism (5.3% vs. 6.2%, p = 0.38), composite major + clinically relevant nonmajor bleeding (9.8% vs. 11.5%, p = 0.18), and all-cause mortality (10.7% vs. 12.8%, p = 0.12) were similar between patients receiving factor Xa inhibitors versus warfarin.CONCLUSION:
No differences in safety or effectiveness were noted between factor Xa inhibitors versus warfarin. These findings provide encouraging evidence to support the use of factor Xa inhibitors in low-body-weight patients.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
6_ODS3_enfermedades_notrasmisibles
Problema de salud:
6_obesity
/
6_venous_thromboembolic_disease
Asunto principal:
Fibrilación Atrial
/
Accidente Cerebrovascular
/
Tromboembolia Venosa
Límite:
Adult
/
Humans
Idioma:
En
Revista:
Pharmacotherapy
Año:
2024
Tipo del documento:
Article
País de afiliación:
Estados Unidos