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First-in-human in-vivo depiction of paraganglioma metabolism by hyperpolarised 13C-magnetic resonance.
Chowdhury, Rafat; Moorthy, Myuri; Smith, Lorna; Mueller, Christoph A; Gong, Fiona; Rogers, Harriet J; Papoutsaki, Marianthi-Vasiliki; Syer, Tom; Brembilla, Giorgio; Singh, Saurabh; Retter, Adam; Parry, Thomas; Clemente, Joey; Caselton, Lucy; Jeraj, Hassan; Bullock, Max; Mathew, Manju; Chung, Teng Teng; Akker, Scott; Chapple, Paul; Salsbury, Grace A; Bainbridge, Alan; Atkinson, David; Gadian, David G; Srirangalingam, Umasuthan; Punwani, Shonit.
Afiliación
  • Chowdhury R; Centre for Medical Imaging, Division of Medicine, University College London, London, UK.
  • Moorthy M; Department of Endocrinology, University College London Hospital, London, UK.
  • Smith L; Centre for Medical Imaging, Division of Medicine, University College London, London, UK.
  • Gong F; Centre for Medical Imaging, Division of Medicine, University College London, London, UK.
  • Rogers HJ; Centre for Medical Imaging, Division of Medicine, University College London, London, UK.
  • Papoutsaki MV; Centre for Medical Imaging, Division of Medicine, University College London, London, UK.
  • Syer T; Centre for Medical Imaging, Division of Medicine, University College London, London, UK.
  • Brembilla G; Centre for Medical Imaging, Division of Medicine, University College London, London, UK.
  • Singh S; Centre for Medical Imaging, Division of Medicine, University College London, London, UK.
  • Retter A; Centre for Medical Imaging, Division of Medicine, University College London, London, UK.
  • Parry T; Centre for Medical Imaging, Division of Medicine, University College London, London, UK.
  • Clemente J; Centre for Medical Imaging, Division of Medicine, University College London, London, UK.
  • Caselton L; Centre for Medical Imaging, Division of Medicine, University College London, London, UK.
  • Jeraj H; Centre for Medical Imaging, Division of Medicine, University College London, London, UK.
  • Bullock M; Centre for Medical Imaging, Division of Medicine, University College London, London, UK.
  • Mathew M; Centre for Medical Imaging, Division of Medicine, University College London, London, UK.
  • Chung TT; Department of Endocrinology, University College London Hospital, London, UK.
  • Akker S; Department of Endocrinology, St Bartholomew's Hospital, London, UK.
  • Chapple P; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
  • Salsbury GA; Department of Endocrinology, University College London Hospital, London, UK.
  • Bainbridge A; Department of Medical Physics and Biomedical Engineering, University College London Hospitals NHS Foundation Trust, London, UK.
  • Atkinson D; Centre for Medical Imaging, Division of Medicine, University College London, London, UK.
  • Gadian DG; UCL Great Ormond Street Institute of Child Health, London, UK.
  • Srirangalingam U; Department of Endocrinology, University College London Hospital, London, UK.
BJR Case Rep ; 9(6): 20220089, 2023 Nov.
Article en En | MEDLINE | ID: mdl-37928705
ABSTRACT
Phaeochromocytomas (PCC) and paragangliomas (PGL), cumulatively referred to as PPGLs, are neuroendocrine tumours arising from neural crest-derived cells in the sympathetic and parasympathetic nervous systems. Predicting future tumour behaviour and the likelihood of metastatic disease remains problematic as genotype-phenotype correlations are limited, the disease has variable penetrance and, to date, no reliable molecular, cellular or histological markers have emerged. Tumour metabolism quantification can be considered as a method to delineating tumour aggressiveness by utilising hyperpolarised 13 C-MR (HP-MR). The technique may provide an opportunity to non-invasively characterise disease behaviour. Here, we present the first instance of the analysis of PPGL metabolism via HP-MR in a single case.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: BJR Case Rep Año: 2023 Tipo del documento: Article País de afiliación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: BJR Case Rep Año: 2023 Tipo del documento: Article País de afiliación: Reino Unido