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Clinical features and outcomes of patients with muscle-specific kinase antibody-positive myasthenia gravis in Japan.
Yasuda, Manato; Uzawa, Akiyuki; Kuwabara, Satoshi; Suzuki, Shigeaki; Akamine, Hiroyuki; Onishi, Yosuke; Ozawa, Yukiko; Kawaguchi, Naoki; Kubota, Tomoya; Takahashi, Masanori P; Suzuki, Yasushi; Watanabe, Genya; Kimura, Takashi; Sugimoto, Takamichi; Samukawa, Makoto; Minami, Naoya; Masuda, Masayuki; Konno, Shingo; Nagane, Yuriko; Utsugisawa, Kimiaki.
Afiliación
  • Yasuda M; Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan.
  • Uzawa A; Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan. Electronic address: auzawa@chiba-u.jp.
  • Kuwabara S; Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan.
  • Suzuki S; Department of Neurology, Keio University School of Medicine, Tokyo, Japan.
  • Akamine H; Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan.
  • Onishi Y; Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan.
  • Ozawa Y; Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan.
  • Kawaguchi N; Department of Neurology, Neurology Chiba Clinic, Chiba, Japan.
  • Kubota T; Department of Clinical Laboratory and Biomedical Sciences, Division of Health Sciences, Osaka University Graduate School of Medicine, Osaka, Japan.
  • Takahashi MP; Department of Clinical Laboratory and Biomedical Sciences, Division of Health Sciences, Osaka University Graduate School of Medicine, Osaka, Japan.
  • Suzuki Y; Department of Neurology, National Hospital Organization Sendai Medical Center, Sendai, Japan.
  • Watanabe G; Department of Neurology, National Hospital Organization Sendai Medical Center, Sendai, Japan.
  • Kimura T; Department of Neurology, Hyogo Medical University, Nishinomiya, Japan.
  • Sugimoto T; Department of Clinical Neuroscience and Therapeutics, Hiroshima University, Hiroshima, Japan.
  • Samukawa M; Department of Neurology, Kindai University Faculty of Medicine, Osaka, Japan.
  • Minami N; Department of Neurology, National Hospital Organization Hokkaido Medical Center, Sapporo, Japan.
  • Masuda M; Department of Neurology, Tokyo Medical University, Tokyo, Japan.
  • Konno S; Department of Neurology, Toho University Ohashi Medical Center, Tokyo, Japan.
  • Nagane Y; Department of Neurology, Hanamaki General Hospital, Hanamaki, Japan.
  • Utsugisawa K; Department of Neurology, Hanamaki General Hospital, Hanamaki, Japan.
J Neuroimmunol ; 385: 578241, 2023 12 15.
Article en En | MEDLINE | ID: mdl-37952282
ABSTRACT
This study included 51 patients with muscle-specific kinase antibody-positive myasthenia gravis (MuSK-MG) from a Japanese multicenter survey to examine clinical features and outcomes. Median onset age was 37 years and female predominance was observed. All patients developed generalized symptoms and almost all (50/51) patients had bulbar symptoms. About half of the patients met the criteria for refractory MG. The refractory group had a lower age of onset, higher severity scores, and higher maximum daily doses of oral prednisolone compared to the nonrefractory group. The outcomes for MuSK-MG patients in Japan are not favorable, indicating the need for more aggressive treatment.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Miastenia Gravis Límite: Adult / Female / Humans / Male País/Región como asunto: Asia Idioma: En Revista: J Neuroimmunol Año: 2023 Tipo del documento: Article País de afiliación: Japón
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Miastenia Gravis Límite: Adult / Female / Humans / Male País/Región como asunto: Asia Idioma: En Revista: J Neuroimmunol Año: 2023 Tipo del documento: Article País de afiliación: Japón