Frequent loss-of-function mutations in the AMPK-&#945;2 catalytic subunit suggest a tumour suppressor role in human skin cancers.

Ross, Fiona A; Hawley, Simon A; Russell, Fiona M; Goodman, Nicola; Hardie, D Grahame

Frequent loss-of-function mutations in the AMPK-α2 catalytic subunit suggest a tumour suppressor role in human skin cancers.

Ross, Fiona A; Hawley, Simon A; Russell, Fiona M; Goodman, Nicola; Hardie, D Grahame.

Afiliación

Ross FA; Division of Cell Signalling & Immunology, School of Life Sciences, University of Dundee, Scotland, U.K.
Hawley SA; Division of Cell Signalling & Immunology, School of Life Sciences, University of Dundee, Scotland, U.K.
Russell FM; Division of Cell Signalling & Immunology, School of Life Sciences, University of Dundee, Scotland, U.K.
Goodman N; Division of Cell Signalling & Immunology, School of Life Sciences, University of Dundee, Scotland, U.K.
Hardie DG; Division of Cell Signalling & Immunology, School of Life Sciences, University of Dundee, Scotland, U.K.

Biochem J ; 480(23): 1951-1968, 2023 12 13.

Article en En | MEDLINE | ID: mdl-37962491

Asunto(s)

Melanoma; Neoplasias Cutáneas; Animales; Humanos; Ratones; Adenosina Trifosfato/metabolismo; Proteínas Quinasas Activadas por AMP/genética; Proteínas Quinasas Activadas por AMP/metabolismo; Dominio Catalítico; Melanoma/genética; Mutación; Neoplasias Cutáneas/genética

Palabras clave

AMPK; melanoma; point mutations; skin cancer; tumour suppressors

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Cutáneas / Melanoma Límite: Animals / Humans Idioma: En Revista: Biochem J Año: 2023 Tipo del documento: Article País de afiliación: Reino Unido

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