Separating the Good from the Bad: Tumor-Infiltrating Tregs Have Increased Fucosylation.
Cancer Immunol Res
; 11(12): 1570, 2023 12 01.
Article
en En
| MEDLINE
| ID: mdl-37966514
ABSTRACT
Regulatory T cells (Treg) can suppress antitumor immune responses, and their presence in tumors is associated with worse prognoses in most cancers. Strategies to neutralize Treg-mediated suppression in tumors without immune-related adverse events, however, are challenging due to the essential role of Tregs in maintaining immune homeostasis. In this issue, Pinioti and colleagues identify fucosylation as a critical regulator of Treg function in tumors that can be targeted therapeutically without impacting immune homeostasis. See related article by Pinioti et al., p. 1611 (3) .
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias
Límite:
Humans
Idioma:
En
Revista:
Cancer Immunol Res
Año:
2023
Tipo del documento:
Article