Symptoms of mental disorders and oral contraception use: A systematic review and meta-analysis.
Front Neuroendocrinol
; 72: 101111, 2024 01.
Article
en En
| MEDLINE
| ID: mdl-37967755
ABSTRACT
Worldwide, over 150 million adolescent and adult women use oral contraceptives (OC). An association between OC-use and the emergence of symptoms of mental disorders has been suggested. This systematic review and meta-analysis provide an overview of published research regarding symptoms of mental disorders in association with OC-use, factoring the influence of OC types, age of first-use, duration of OC-intake, and previous diagnoses of mental disorders. A systematic literature search was conducted between June-July 2022. 22 studies were included. While most found no significant OC-use effects on mental symptoms, some hinted at OCs as a potential risk. The existing evidence regarding the potential link between progestin-only OC-use and an elevated risk of mental symptoms in comparison to combined OC-use remains inconclusive. However, due to emerging indications suggesting that the formulation of OC might play a role in mental health outcomes, this topic warrants further investigation. Moreover, indications of an increased risk for depressive symptoms in adolescent OC-users should be noted. Hence, while general population effects seem unlikely, they cannot be completely disregarded. The decision on OC-use should depend on the patient's medical history and should be re-evaluated regularly.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Anticonceptivos Orales
/
Trastornos Mentales
Tipo de estudio:
Systematic_reviews
Límite:
Adolescent
/
Adult
/
Female
/
Humans
Idioma:
En
Revista:
Front Neuroendocrinol
Año:
2024
Tipo del documento:
Article
País de afiliación:
Alemania