Protective effects of Silymarin on testicular torsion/detorsion in rats.
Eur Rev Med Pharmacol Sci
; 27(21): 10446-10453, 2023 Nov.
Article
en En
| MEDLINE
| ID: mdl-37975368
ABSTRACT
OBJECTIVE:
The present research aimed to study the possible protective effects of Silymarin on testicular I/R injury in a rat model evaluated through histopathology and biochemical parameters. MATERIALS ANDMETHODS:
This research investigated the impact of Silymarin on IR damage in male Wistar albino rats. Animals were divided into three groups group 1 (sham), group 2 (IR), and group 3 (IR+Silymarin).RESULTS:
There were no notable differences in the levels of malondialdehyde (MDA), myeloperoxidase (MPO), and glutathione (GSH) across the three groups (p=0.260, p=0.486 and p=0.803, respectively). Contrarily, the total antioxidant status (TAS) levels exhibited significant variations between groups (p=0.001). The total oxidant status (TOS) levels also differed significantly between groups (p=0.004). The tissue evaluations uncovered substantial differences in the Johnson score, which is used to gauge testicular damage. A distinct contrast was seen between Group 1 and Group 2, and also between Group 2 and Group 3, with an all-encompassing p-value lower than 0.01. The same significant disparities were found for the percentages of Bax and Annexin V immunostaining (p<0.01 for each), reflecting the inflammation and apoptosis brought about by ischemia-reperfusion and the protective effects of the treatment.CONCLUSIONS:
The outcomes of the current investigation showed that Silymarin could be a valuable agent for reducing testicular tissue damage following I/R injury.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Silimarina
/
Torsión del Cordón Espermático
/
Daño por Reperfusión
Límite:
Animals
/
Humans
/
Male
Idioma:
En
Revista:
Eur Rev Med Pharmacol Sci
Asunto de la revista:
FARMACOLOGIA
/
TOXICOLOGIA
Año:
2023
Tipo del documento:
Article
País de afiliación:
Turquía