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Impact of painful physical symptoms on first-episode major depressive disorder in adults with subthreshold depressive symptoms: A prospective cohort study.
Li, Xiuwen; Zhang, Huimin; Wu, Keying; Fan, Beifang; Guo, Lan; Liao, Yuhua; McIntyre, Roger S; Wang, Wanxin; Liu, Yifeng; Shi, Jingman; Chen, Yan; Shen, Manjun; Wang, Hongqiong; Li, Lingjiang; Han, Xue; Lu, Ciyong.
Afiliación
  • Li X; Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-sen University, 510080 Guangzhou, People's Republic of China; Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Sun Yat-sen University, 510080 Guangzhou, People's Republic of China; Guangdong Enginee
  • Zhang H; Department of Psychiatry, Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, People's Republic of China.
  • Wu K; Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-sen University, 510080 Guangzhou, People's Republic of China; Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Sun Yat-sen University, 510080 Guangzhou, People's Republic of China; Guangdong Enginee
  • Fan B; Department of Psychiatry, Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, People's Republic of China.
  • Guo L; Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-sen University, 510080 Guangzhou, People's Republic of China; Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Sun Yat-sen University, 510080 Guangzhou, People's Republic of China; Guangdong Enginee
  • Liao Y; Department of Psychiatry, Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, People's Republic of China.
  • McIntyre RS; Mood Disorders Psychopharmacology Unit, University Health Network, Canada; Department of Psychiatry, University of Toronto, Canada; Department of Pharmacology, University of Toronto, Canada; Brain and Cognition Discovery Foundation, Toronto, ON, Canada; Braxia Health, Mississauga, ON, Canada.
  • Wang W; Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-sen University, 510080 Guangzhou, People's Republic of China; Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Sun Yat-sen University, 510080 Guangzhou, People's Republic of China; Guangdong Enginee
  • Liu Y; Department of Psychiatry, Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, People's Republic of China.
  • Shi J; Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-sen University, 510080 Guangzhou, People's Republic of China; Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Sun Yat-sen University, 510080 Guangzhou, People's Republic of China; Guangdong Enginee
  • Chen Y; Department of Psychiatry, Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, People's Republic of China.
  • Shen M; Department of Psychiatry, Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, People's Republic of China.
  • Wang H; Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-sen University, 510080 Guangzhou, People's Republic of China; Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Sun Yat-sen University, 510080 Guangzhou, People's Republic of China; Guangdong Enginee
  • Li L; Mental Health Institute of the Second Xiangya Hospital, Central South University, Changsha, People's Republic of China.
  • Han X; Department of Psychiatry, Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, People's Republic of China. Electronic address: xuehan_sz@hotmail.com.
  • Lu C; Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-sen University, 510080 Guangzhou, People's Republic of China; Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Sun Yat-sen University, 510080 Guangzhou, People's Republic of China; Guangdong Enginee
Gen Hosp Psychiatry ; 86: 1-9, 2024.
Article en En | MEDLINE | ID: mdl-38029479
ABSTRACT

OBJECTIVE:

To investigate the impact of baseline painful physical symptoms (PPS) on subsequent first-episode major depressive disorder (MDD) in adults with subthreshold depressive symptoms, including subgroup analyses to assess whether the associations differ in individuals with and without physical diseases.

METHODS:

A total of 2343 adults with subthreshold depressive symptoms were recruited at 34 primary health care centers. PPS were measured at baseline. First-episode MDD during follow-up was diagnosed by professional psychiatrists using the Mini-International Neuropsychiatric Interview.

RESULTS:

Baseline PPS showed independent impacts on first-episode MDD in adults with subthreshold depressive symptoms without physical diseases, but not in those with physical diseases. A non-linear association (P < 0.001) was observed between PPS burden and the risk of first-episode MDD. The HRs for first-episode MDD exhibited a rapidly increasing trend between PPS burden scores of 10-16, and maintained consistently high when scores exceeded 16. The analyses for specific PPS revealed that headache, neck pain, and heart or chest pain were independently associated with first-episode MDD in participants without physical diseases, the HRs were 1.57 (1.15-2.36), 1.53 (1.02-2.30), and 1.69 (1.14-2.50), respectively. Further network analysis demonstrated that heart or chest pain serves as a bridge symptom among the seven specific PPS and first-episode MDD in those without physical diseases.

CONCLUSION:

PPS burden and heart or chest pain may be significant indicators for first-episode MDD in adults with subthreshold depressive symptoms without physical diseases. Future studies should investigate whether interventions targeting PPS can prevent episode MDD in this subthreshold population.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastorno Depresivo Mayor Límite: Adult / Humans Idioma: En Revista: Gen Hosp Psychiatry Año: 2024 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastorno Depresivo Mayor Límite: Adult / Humans Idioma: En Revista: Gen Hosp Psychiatry Año: 2024 Tipo del documento: Article
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