High dose Vitamin C inhibits PD-L1 by ROS-pSTAT3 signal pathway and enhances T cell function in TNBC.

Zhao, Xixi; Liu, Mengjie; Li, Chaofan; Liu, Xiaoxiao; Zhao, Jiaqi; Ma, Hongbing; Zhang, Shuqun; Qu, Jingkun

Zhao, Xixi; Liu, Mengjie; Li, Chaofan; Liu, Xiaoxiao; Zhao, Jiaqi; Ma, Hongbing; Zhang, Shuqun; Qu, Jingkun.

Afiliación

Zhao X; Department of Radiation Oncology, The Second Affiliated Hospital of Xi'an Jiaotong University, 157 West Fifth Street, Xi'an 710004, Shaanxi, PR China.
Liu M; Department of Oncology, The Second Affiliated Hospital of Xi'an Jiaotong University, 157 West Fifth Street, Xi'an 710004, Shaanxi, PR China.
Li C; Department of Oncology, The Second Affiliated Hospital of Xi'an Jiaotong University, 157 West Fifth Street, Xi'an 710004, Shaanxi, PR China.
Liu X; Department of Radiation Oncology, The Second Affiliated Hospital of Xi'an Jiaotong University, 157 West Fifth Street, Xi'an 710004, Shaanxi, PR China.
Zhao J; Department of Cardiology, The Second Affiliated Hospital of Xi'an Jiaotong University, 157 West Fifth Street, Xi'an 710004, Shaanxi, PR China.
Ma H; Department of Radiation Oncology, The Second Affiliated Hospital of Xi'an Jiaotong University, 157 West Fifth Street, Xi'an 710004, Shaanxi, PR China.
Zhang S; Department of Oncology, The Second Affiliated Hospital of Xi'an Jiaotong University, 157 West Fifth Street, Xi'an 710004, Shaanxi, PR China. Electronic address: shuqun_zhang1971@163.com.
Qu J; Department of Oncology, The Second Affiliated Hospital of Xi'an Jiaotong University, 157 West Fifth Street, Xi'an 710004, Shaanxi, PR China. Electronic address: qujingkun@xjtu.edu.cn.

Int Immunopharmacol ; 126: 111321, 2024 Jan 05.

Article en En | MEDLINE | ID: mdl-38041955

Asunto(s)

Antineoplásicos; Neoplasias de la Mama Triple Negativas; Humanos; Animales; Ratones; Antígeno B7-H1/metabolismo; Especies Reactivas de Oxígeno/metabolismo; Neoplasias de la Mama Triple Negativas/patología; Antineoplásicos/uso terapéutico; Transducción de Señal; Ácido Ascórbico/uso terapéutico; Linfocitos T CD8-positivos/metabolismo; Línea Celular Tumoral; Microambiente Tumoral

Palabras clave

Immunotherapy; PD-L1; TNBC; Vitamin C

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama Triple Negativas / Antineoplásicos Límite: Animals / Humans Idioma: En Revista: Int Immunopharmacol Asunto de la revista: ALERGIA E IMUNOLOGIA / FARMACOLOGIA Año: 2024 Tipo del documento: Article

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