Strategies for high cell density cultivation of Akkermansia muciniphila and its potential metabolism.
Microbiol Spectr
; 12(1): e0238623, 2024 Jan 11.
Article
en En
| MEDLINE
| ID: mdl-38059626
ABSTRACT
IMPORTANCE Currently, there is significant interest in Akkermansia muciniphila as a promising next-generation probiotic, making it a hot topic in scientific research. However, to achieve efficient industrial production, there is an urgent need to develop an in vitro culture method to achieve high biomass using low-cost carbon sources such as glucose. This study aims to explore the high-density fermentation strategy of A. muciniphila by optimizing the culture process. This study also employs techniques such as LC-MS and RNA-Seq to explain the possible regulatory mechanism of high-density cell growth and increased cell surface hydrophobicity facilitating cell colonization of the gut in vitro culture. Overall, this research sheds light on the potential of A. muciniphila as a probiotic and provides valuable insights for future industrial production.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Carbono
/
Akkermansia
Idioma:
En
Revista:
Microbiol Spectr
Año:
2024
Tipo del documento:
Article