Successful treatment of prolonged cholestasis following hepatitis A infection in a child with oral steroid therapy.
BMJ Case Rep
; 16(12)2023 Dec 09.
Article
en En
| MEDLINE
| ID: mdl-38087479
ABSTRACT
Hepatitis A is a common cause of acute infectious hepatitis in children, transmitted through the faeco-oral route. Although mostly self-limiting, cholestasis is a rare but known complication of acute hepatitis A in children. This report presents an adolescent girl who developed cholestatic features following hepatitis A infection and successful treatment with oral steroid therapy. Prolonged cholestasis jaundice (PCJ) is a known manifestation of hepatitis A infection, characterised by prolonged fever, pruritus and jaundice. While the exact mechanisms causing PCJ are not fully understood, immunological-mediated responses could play a role. Treatment options for PCJ are limited, and there is no currently accepted standard of care. Steroids have shown promise in treating PCJ, as observed in this case and a few other reported cases. When other therapies fail to alleviate symptoms, corticosteroids should be considered as a potential treatment option. However, further studies are required to conclusively establish their efficacy.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Colestasis
/
Ictericia Obstructiva
/
Hepatitis
/
Hepatitis A
/
Ictericia
Límite:
Adolescent
/
Female
/
Humans
Idioma:
En
Revista:
BMJ Case Rep
Año:
2023
Tipo del documento:
Article
País de afiliación:
India