Microbiome diversity protects against pathogens by nutrient blocking.
Science
; 382(6676): eadj3502, 2023 12 15.
Article
en En
| MEDLINE
| ID: mdl-38096285
ABSTRACT
The human gut microbiome plays an important role in resisting colonization of the host by pathogens, but we lack the ability to predict which communities will be protective. We studied how human gut bacteria influence colonization of two major bacterial pathogens, both in vitro and in gnotobiotic mice. Whereas single species alone had negligible effects, colonization resistance greatly increased with community diversity. Moreover, this community-level resistance rested critically upon certain species being present. We explained these ecological patterns through the collective ability of resistant communities to consume nutrients that overlap with those used by the pathogen. Furthermore, we applied our findings to successfully predict communities that resist a novel target strain. Our work provides a reason why microbiome diversity is beneficial and suggests a route for the rational design of pathogen-resistant communities.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
3_ND
Problema de salud:
3_neglected_diseases
/
3_zoonosis
Asunto principal:
Infecciones por Salmonella
/
Salmonella typhimurium
/
Infecciones por Klebsiella
/
Interacciones Huésped-Patógeno
/
Microbioma Gastrointestinal
/
Klebsiella pneumoniae
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Science
Año:
2023
Tipo del documento:
Article
País de afiliación:
Reino Unido