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Polypharmacy and pattern of medication use among patients with gastroesophageal reflux disease: results from Pars Cohort study.
Ghamar-Shooshtari, Arash; Rahimian, Zahra; Poustchi, Hossein; Mohammadi, Zahra; Mesgarpour, Bita; Akbari, Mohammadreza; Kamalipour, Alireza; Abdipour-Mehrian, Seyed Reza; Hashemi, Elham-Sadat; Zare, Pooria; Lankarani, Kamran Bagheri; Malekzadeh, Reza; Malekzadeh, Fatemeh; Vardanjani, Hossein Molavi.
Afiliación
  • Ghamar-Shooshtari A; MD-MPH Department, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Rahimian Z; Ophtalmology Resident of Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.
  • Poustchi H; MD-MPH Department, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Mohammadi Z; Liver and Pancreatobiliary Disease Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
  • Mesgarpour B; Liver and Pancreatobiliary Disease Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
  • Akbari M; Vice Chancellery for Research and Technology, National Institute for Medical Research and Development (NIMAD), Tehran, Iran.
  • Kamalipour A; MD-MPH Department, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Abdipour-Mehrian SR; Shiraz Nephro-Urology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Hashemi ES; Department of Ophthalmology, Shiley Eye Institute, Hamilton Glaucoma Center, University of California, San Diego, CA, USA.
  • Zare P; Health Policy Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Lankarani KB; MD-MPH Department, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Malekzadeh R; MD-MPH Department, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Malekzadeh F; Pathology Resident of Kermanshah University of Medical Sciences, Kermanshah, Iran.
  • Vardanjani HM; Health Policy Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran.
BMC Gastroenterol ; 23(1): 439, 2023 Dec 14.
Article en En | MEDLINE | ID: mdl-38097949
ABSTRACT

BACKGROUND:

Gastroesophageal Reflux Disease (GERD) is a common chronic condition. Its chronic nature may affect the pattern of medication use. This study aimed to investigate the prevalence, associated factors, and patterns of polypharmacy and medication use among GERD patients in southwestern Iran.

METHODS:

We used data from the Pars Cohort Study. We classified drugs using the Anatomical Therapeutic Chemical classification system. The Lexicomp® database was used to assess potential drug-drug interactions. Multivariable Poisson regression was applied. Adjusted prevalence ratio (PR) and its 95% confidence interval (CI) were estimated.

RESULTS:

A total of 9262 participants were included. Among 2,325 patients with GERD, age-standardized prevalence of polypharmacy was 9.5% (95% CI 7.5%, 11.6%) in males, and 19.3% (95% CI 17.2%, 21.4%) in females. The PR of experiencing Polypharmacy by GERD patients compared to non-GERD patients was 1.82 (95% CI 1.61, 2.05%). Multimorbidity (PR 3.33; CI 2.66, 4.15), gender (PR 1.68; CI 1.30, 2.18), and metabolic syndrome (PR 1.77; CI 1.45, 2.15) were associated with polypharmacy among GERD patients. Drugs for acid-related disorders were the most common used drugs among men, women and elders. We found that 13.9%, 4.2%, and 1.1% of GERD patients had type C, D and X drug interactions, respectively.

CONCLUSION:

GERD is correlated with a higher prevalence of polypharmacy. Among GERD patients, females, those with multi-morbidities, and those with metabolic syndrome may be affected more by polypharmacy. Considering the fairly high rate of interactions identified, a review of the medication list is essential when approaching GERD patients, and physicians must check for medications that may worsen GERD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Reflujo Gastroesofágico / Síndrome Metabólico Límite: Aged / Female / Humans / Male Idioma: En Revista: BMC Gastroenterol Asunto de la revista: GASTROENTEROLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Irán

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Reflujo Gastroesofágico / Síndrome Metabólico Límite: Aged / Female / Humans / Male Idioma: En Revista: BMC Gastroenterol Asunto de la revista: GASTROENTEROLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Irán
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