LMNA::NTRK1 Fusion-positive Leiomyosarcoma: Discrepancy between DNA-based Comprehensive Genomic Profiling and RNA Sequencing.
Intern Med
; 2023 Dec 18.
Article
en En
| MEDLINE
| ID: mdl-38104989
ABSTRACT
A 26-year-old man presented with a tumor in the left soleus muscle. The tumor was diagnosed as a locally advanced leiomyosarcoma. The patient was treated with irradiation followed by wide resection. One year after surgery, the patient presented with multiple lung metastases. Despite aggressive sequential chemotherapy, systemic metastatic tumors continued to develop. To explore therapeutic options for the patient, we performed DNA-based CGP with FoundationOne® CDx (F1). F1 identified anout-of-strand rearrangement of the NOS1APNTRK1 gene, which has not been previously reported. In contrast, RNA sequencing revealed an in-frame LMNANTRK1 gene, which is an oncogenic fusion gene.
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Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Intern Med
Asunto de la revista:
MEDICINA INTERNA
Año:
2023
Tipo del documento:
Article
País de afiliación:
Japón