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Anti-motion Ultrafast T2 Mapping Technique for Quantitative Detection of the Normal-Appearing Corticospinal Tract Changes in Subacute-Chronic Stroke Patients with Distal Lesions.
Zhang, Yue; Wang, Xiao; Ye, Ming; Li, Zongye; Zhuang, Yuchuan; Yang, Qinqin; Fu, Qichang; Chen, Rui; Gao, Eryuan; Ren, Yanan; Zhang, Yong; Cai, Shuhui; Chen, Zhong; Cai, Congbo; Dong, Yanbo; Bao, Jianfeng; Cheng, Jingliang.
Afiliación
  • Zhang Y; Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, 450000, China (Y.Z., X.W., Z.L., Q.F., R.C., E.G., Y.R., Y.Z., J.B., J.C.).
  • Wang X; Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, 450000, China (Y.Z., X.W., Z.L., Q.F., R.C., E.G., Y.R., Y.Z., J.B., J.C.).
  • Ye M; Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance Research, Xiamen University, Xiamen, 361000, China (M.Y., Q.Y., S.C., Z.C., C.C.).
  • Li Z; Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, 450000, China (Y.Z., X.W., Z.L., Q.F., R.C., E.G., Y.R., Y.Z., J.B., J.C.).
  • Zhuang Y; Department of Imaging Sciences, University of Rochester Medical Center, Rochester, 14627, USA (Y.Z.).
  • Yang Q; Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance Research, Xiamen University, Xiamen, 361000, China (M.Y., Q.Y., S.C., Z.C., C.C.).
  • Fu Q; Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, 450000, China (Y.Z., X.W., Z.L., Q.F., R.C., E.G., Y.R., Y.Z., J.B., J.C.).
  • Chen R; Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, 450000, China (Y.Z., X.W., Z.L., Q.F., R.C., E.G., Y.R., Y.Z., J.B., J.C.).
  • Gao E; Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, 450000, China (Y.Z., X.W., Z.L., Q.F., R.C., E.G., Y.R., Y.Z., J.B., J.C.).
  • Ren Y; Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, 450000, China (Y.Z., X.W., Z.L., Q.F., R.C., E.G., Y.R., Y.Z., J.B., J.C.).
  • Zhang Y; Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, 450000, China (Y.Z., X.W., Z.L., Q.F., R.C., E.G., Y.R., Y.Z., J.B., J.C.).
  • Cai S; Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance Research, Xiamen University, Xiamen, 361000, China (M.Y., Q.Y., S.C., Z.C., C.C.).
  • Chen Z; Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance Research, Xiamen University, Xiamen, 361000, China (M.Y., Q.Y., S.C., Z.C., C.C.).
  • Cai C; Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance Research, Xiamen University, Xiamen, 361000, China (M.Y., Q.Y., S.C., Z.C., C.C.).
  • Dong Y; Institute of Psychology, The Herzen State Pedagogical University of Russia, Saint Petersburg, 190121, Russia (Y.D.).
  • Bao J; Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, 450000, China (Y.Z., X.W., Z.L., Q.F., R.C., E.G., Y.R., Y.Z., J.B., J.C.).
  • Cheng J; Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, 450000, China (Y.Z., X.W., Z.L., Q.F., R.C., E.G., Y.R., Y.Z., J.B., J.C.). Electronic address: fccchengjl@zzu.edu.cn.
Acad Radiol ; 31(6): 2488-2500, 2024 Jun.
Article en En | MEDLINE | ID: mdl-38142175
ABSTRACT
RATIONALE AND

OBJECTIVES:

Stroke patients commonly face challenges during magnetic resonance imaging (MRI) examinations due to involuntary movements. This study aims to overcome these challenges by utilizing multiple overlapping-echo detachment (MOLED) quantitative technology. Through this technology, we also seek to detect microstructural changes of the normal-appearing corticospinal tract (NA-CST) in subacute-chronic stroke patients. MATERIALS AND

METHODS:

79 patients underwent 3.0 T MRI scans, including routine scans and MOLED technique. A deep learning network was utilized for image reconstruction, and the accuracy, reliability, and resistance to motion of the MOLED technique were validated on phantoms and volunteers. Subsequently, we assessed motor dysfunction severity, ischemic lesion volume, T2 values of the bilateral NA-CST, and the T2 ratio (rT2) between the ipsilesional and contralesional NA-CST in patients.

RESULTS:

The MOLED technique showed high accuracy (P < 0.001) and excellent repeatability, with a mean coefficient of variation (CoV) of 1.11%. It provided reliable quantitative results even under head movement, with a mean difference (Meandiff)= 0.28% and a standard deviation difference (SDdiff)= 1.34%. Additionally, the T2 value of the ipsilesional NA-CST was significantly higher than contralesional side (P < 0.001), and a positive correlation was observed between rT2 and the severity of motor dysfunction (rs =0.575, P < 0.001). Furthermore, rT2 successfully predicted post-stroke motor impairment, with an area under the curve (AUC) was 0.883.

CONCLUSION:

The MOLED technique offers significant advantages for quantitatively imaging stroke patients with involuntary movements. Additionally, T2 mapping from MOLED can detect microstructural changes in the NA-CST, potentially aiding in monitoring stroke-induced motor impairment.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tractos Piramidales / Imagen por Resonancia Magnética / Accidente Cerebrovascular Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Acad Radiol Asunto de la revista: RADIOLOGIA Año: 2024 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tractos Piramidales / Imagen por Resonancia Magnética / Accidente Cerebrovascular Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Acad Radiol Asunto de la revista: RADIOLOGIA Año: 2024 Tipo del documento: Article