Acute myeloid leukemia cutis with KMT2A::MLLT3 fusion presenting with leonine facies.
Leuk Res Rep
; 21: 100400, 2024.
Article
en En
| MEDLINE
| ID: mdl-38162585
ABSTRACT
A 63-year-old woman presented with plaques covering 60 % body-surface-area and leonine facies. Blood work showed no diagnostic aberrancies. Skin biopsy contained a malignant CD4+/CD56+ mononuclear cell population concerning for blastic plasmacytoid dendritic cell neoplasm. A later bone marrow biopsy confirmed AML with KMT2AMLLT10 fusion detected by next-generation sequencing (NGS). This patient's LC preceded blood and marrow based symptoms of AML. NGS of the initial skin biopsy should be considered as part of diagnostic guidelines in cases with LC in the differential as this may have led to earlier diagnosis in this case and future cases.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Tipo de estudio:
Guideline
Idioma:
En
Revista:
Leuk Res Rep
Año:
2024
Tipo del documento:
Article
País de afiliación:
Estados Unidos