Cell competition and cancer from Drosophila to mammals.
Oncogenesis
; 13(1): 1, 2024 Jan 03.
Article
en En
| MEDLINE
| ID: mdl-38172609
ABSTRACT
Throughout an individual's life, somatic cells acquire cancer-associated mutations. A fraction of these mutations trigger tumour formation, a phenomenon partly driven by the interplay of mutant and wild-type cell clones competing for dominance; conversely, other mutations function against tumour initiation. This mechanism of 'cell competition', can shift clone dynamics by evaluating the relative status of clonal populations, promoting 'winners' and eliminating 'losers'. This review examines the role of cell competition in the context of tumorigenesis, tumour progression and therapeutic intervention.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Oncogenesis
Año:
2024
Tipo del documento:
Article
País de afiliación:
Reino Unido