Gender and Race Differences in HeartMate3 Left Ventricular Assist Device as a Bridge to Transplantation.
JACC Heart Fail
; 12(8): 1459-1469, 2024 Aug.
Article
en En
| MEDLINE
| ID: mdl-38180429
ABSTRACT
BACKGROUND:
Gender and racial disparities exist after left ventricular assist device (LVAD) implantation. Compared with older devices, the HeartMate 3 (HM3) (Abbott Cardiovascular) has demonstrated improved survival. Whether HM3 differentially improves outcomes by gender or race and ethnic groups is unknown.OBJECTIVES:
The purpose of this study is to examine differences by gender and race in the use of HM3 among patients listed for heart transplantation (HT) and associated waitlist and post-transplant outcomes.METHODS:
The authors examined all patients (20% women, 33% Black) who received LVADs as bridge to transplantation (BTT) between January 2018 and June 2020, in the OPTN (Organ Procurement and Transplantation Network) database. Trends in use of HM3 were evaluated by gender and race. Competing events of death/delisting and transplantation were evaluated using subdistribution hazard models. Post-transplant outcomes were evaluated using multivariate logistic regression adjusted for demographic, clinical, and donor characteristics.RESULTS:
Of 11,524 patients listed for HT during the study period, 955 (8.3%) had HM3 implanted as BTT. Use of HM3 increased for all patients, with no difference in use by gender (P = 0.4) or by race (P = 0.2). Competing risk analysis did not demonstrate differences in transplantation or death/delisting in men compared with women (HT adjusted HR [aHR] 0.92 [95% CI 0.70-1.21]; death/delisting aHR 0.91 [95% CI 0.59-1.42]), although Black patients were transplanted fewer times than White patients (HT aHR 0.72 [95% CI 0.57-0.91], death/delisting aHR 1.36 [95% CI 0.98-1.89]). One-year post-transplant survival was comparable by gender (aHR 0.52 [95% CI 0.21-1.70]) and race (aHR 0.76 [95% CI 0.34-1.70]), with no differences in rates of stroke, acute rejection, or graft failure.CONCLUSIONS:
Use of HM3 among patients listed for HT has increased over time and by gender and race. Black patients with HM3 were less likely to be transplanted compared with White patients, but there were no differences in post-transplant outcomes between these groups or between men and women.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Corazón Auxiliar
/
Listas de Espera
/
Trasplante de Corazón
/
Insuficiencia Cardíaca
Tipo de estudio:
Prognostic_studies
Aspecto:
Determinantes_sociais_saude
Límite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
País/Región como asunto:
America do norte
Idioma:
En
Revista:
JACC Heart Fail
/
JACC. Heart failure (Online)
Año:
2024
Tipo del documento:
Article
País de afiliación:
Estados Unidos