Joint MAPLE: Accelerated joint T1 and T 2 * $$ {{\mathrm{T}}_2}

ABSTRACT

PURPOSE: Quantitative MRI finds important applications in clinical and research studies. However, it is encoding intensive and may suffer from prohibitively long scan times. Accelerated MR parameter mapping techniques have been developed to help address these challenges. Here, an accelerated joint T1, T 2 * $$ {{\mathrm{T}}_2}^{\ast } $$ , frequency and proton density mapping technique with scan-specific self-supervised network reconstruction is proposed to synergistically combine parallel imaging, model-based, and deep learning approaches to speed up parameter mapping. METHODS: Proposed framework, Joint MAPLE, includes parallel imaging, signal modeling, and data consistency blocks which are optimized jointly in a combined loss function. A scan-specific self-supervised reconstruction is embedded into the framework, which takes advantage of multi-contrast data from a multi-echo, multi-flip angle, gradient echo acquisition. RESULTS: In comparison with parallel reconstruction techniques powered by low-rank methods, emerging scan specific networks, and model-based T 2 * $$ {{\mathrm{T}}_2}^{\ast } $$ estimation approaches, the proposed framework reduces the reconstruction error in parameter maps by approximately two-fold on average at acceleration rates as high as R = 16 with uniform sampling. It can outperform evaluated parallel reconstruction techniques up to four-fold on average in the presence of challenging sub-sampling masks. It is observed that Joint MAPLE performs well at extreme acceleration rates of R = 25 and R = 36 with error values less than 20%. CONCLUSION: Joint MAPLE enables higher fidelity parameter estimation at high acceleration rates by synergistically combining parallel imaging and model-based parameter mapping and exploiting multi-echo, multi-flip angle datasets. Utilizing a scan-specific self-supervised reconstruction obviates the need for large data sets for training while improving the parameter estimation ability.