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Cost-effectiveness of ChloraSolv in treating hard-to-heal venous leg ulcers.
Guest, Julian F; Apelqvist, Jan.
Afiliación
  • Guest JF; Catalyst Consultants, Poole, UK.
  • Apelqvist J; Department of Endocrinology, University Hospital of Malmö, Sweden.
J Wound Care ; 33(1): 4-13, 2024 Jan 02.
Article en En | MEDLINE | ID: mdl-38197275
ABSTRACT

OBJECTIVE:

To estimate whether the topical, amino acid-buffered hypochlorite debriding gel ChloraSolv (RLS Global AB, Sweden) could potentially afford the UK's health services a cost-effective intervention for hard-to-heal venous leg ulcers (VLUs).

METHOD:

A Markov model representing the management of hard-to-heal VLUs with ChloraSolv plus standard care (SC) or SC alone was populated with inputs from an indirect comparison of two propensity score-matched cohorts. The model estimated the relative cost-effectiveness of ChloraSolv in terms of the incremental cost per quality-adjusted life year (QALY) gained at 2021/2022 prices.

RESULTS:

Addition of ChloraSolv to an SC protocol was found to increase the probability of healing by 36% (from 0.14 to 0.19) after 12 weeks, and by 79% (from 0.24 to 0.43) after 24 weeks. This led to a marginal increase in health-related quality of life. Treatment with ChloraSolv plus SC instead of SC alone reduced the total cost of wound management by 8% (£189 per VLU) at 12 weeks and by 18% (£796 per VLU) at 24 weeks. Use of ChloraSolv was estimated to improve health outcomes at reduced cost. Sensitivity analysis showed that use of ChloraSolv plus SC remained a cost-effective treatment with plausible variations in costs and effectiveness.

CONCLUSION:

Within the limitations of the study, the addition of ChloraSolv to an SC protocol potentially affords a cost-effective treatment to the UK's health services for managing hard-to-heal VLUs.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 1_ASSA2030 Problema de salud: 1_financiamento_saude Asunto principal: Calidad de Vida / Úlcera Varicosa Tipo de estudio: Guideline / Health_economic_evaluation / Prognostic_studies Aspecto: Patient_preference Límite: Humans Idioma: En Revista: J Wound Care Asunto de la revista: ENFERMAGEM Año: 2024 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 1_ASSA2030 Problema de salud: 1_financiamento_saude Asunto principal: Calidad de Vida / Úlcera Varicosa Tipo de estudio: Guideline / Health_economic_evaluation / Prognostic_studies Aspecto: Patient_preference Límite: Humans Idioma: En Revista: J Wound Care Asunto de la revista: ENFERMAGEM Año: 2024 Tipo del documento: Article
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