[Global environmental changes and the epithelial barrier hypothesis]. / Globale Umweltveränderungen und die "epithelial barrier hypothesis".
Dermatologie (Heidelb)
; 75(2): 118-125, 2024 Feb.
Article
en De
| MEDLINE
| ID: mdl-38212394
ABSTRACT
BACKGROUND:
The global burden of noncommunicable diseases (NCD) has seen a strong increase in recent decades and attributable to the influence of environmental factors. For a multitude of diseases an association with epithelial barrier damage has been reported.OBJECTIVE:
This article provides an overview of the health effects of environmental pollution in the context of the epithelial barrier hypothesis of Cezmi Akdis. Additionally, exemplary mechanisms of a barrier damage are described. Finally, possible preventive and therapeutic consequences are discussed. MATERIAL ANDMETHODS:
The PubMed database was searched for the relevant topics and selected literature was reviewed.RESULTS:
A wide variety of substances can damage the epithelial barriers of the skin, lungs and gastrointestinal tract. The rise in the prevalences of atopic diseases could (partly) be due to an increased exposure to barrier-damaging substances, such as particulate matter and laundry detergents. A possible pathogenetic mechanism is the initiation and maintenance of an immune response by subepithelial penetration of microorganisms through damaged epithelia.CONCLUSION:
Based on the epithelial barrier hypothesis new therapeutic and prevention strategies can be developed. The regulation of hazardous chemicals and the fight against environmental pollution and climate change are necessary to reduce the burden of disease.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
2_ODS3
Problema de salud:
2_quimicos_contaminacion
Asunto principal:
Piel
/
Contaminación Ambiental
Tipo de estudio:
Risk_factors_studies
Aspecto:
Determinantes_sociais_saude
Idioma:
De
Revista:
Dermatologie (Heidelb)
Año:
2024
Tipo del documento:
Article