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Intrathecal Baclofen Infusion-Botulinum Toxin Combined Treatment Efficacy in the Management of Spasticity due to Cerebral Palsy.
Marvulli, Riccardo; Lagioia, Giuseppa; Ianieri, Giancarlo; Dell'Olio, Lucrezia; Zonno, Alessandra; Riccardi, Mariagrazia; Sinisi, Rosa Bianca; Rizzo, Laura Belinda; Farì, Giacomo; Megna, Marisa; Ranieri, Maurizio.
Afiliación
  • Marvulli R; Department of Translational Biomedicine and Neuroscience (DiBraiN), Aldo Moro University, G. Cesare Place 11, 70125, Bari, Italy.
  • Lagioia G; Department of Translational Biomedicine and Neuroscience (DiBraiN), Aldo Moro University, G. Cesare Place 11, 70125, Bari, Italy.
  • Ianieri G; Department of Translational Biomedicine and Neuroscience (DiBraiN), Aldo Moro University, G. Cesare Place 11, 70125, Bari, Italy.
  • Dell'Olio L; Department of Translational Biomedicine and Neuroscience (DiBraiN), Aldo Moro University, G. Cesare Place 11, 70125, Bari, Italy.
  • Zonno A; Department of Translational Biomedicine and Neuroscience (DiBraiN), Aldo Moro University, G. Cesare Place 11, 70125, Bari, Italy.
  • Riccardi M; Department of Translational Biomedicine and Neuroscience (DiBraiN), Aldo Moro University, G. Cesare Place 11, 70125, Bari, Italy.
  • Sinisi RB; Department of Translational Biomedicine and Neuroscience (DiBraiN), Aldo Moro University, G. Cesare Place 11, 70125, Bari, Italy.
  • Rizzo LB; Department of Translational Biomedicine and Neuroscience (DiBraiN), Aldo Moro University, G. Cesare Place 11, 70125, Bari, Italy.
  • Farì G; Department of Biological and Environmental Science and Technologies (Di.S.Te.B.A.), University of Salento, 73100 Lecce, Italy.
  • Megna M; Department of Translational Biomedicine and Neuroscience (DiBraiN), Aldo Moro University, G. Cesare Place 11, 70125, Bari, Italy.
  • Ranieri M; Department of Translational Biomedicine and Neuroscience (DiBraiN), Aldo Moro University, G. Cesare Place 11, 70125, Bari, Italy.
CNS Neurol Disord Drug Targets ; 23(7): 917-926, 2024.
Article en En | MEDLINE | ID: mdl-38213169
ABSTRACT

BACKGROUND:

Cerebral Palsy (CP) is a group of permanent, but not unchanging, disorders of movement and/or posture and motor function, which are due to a non-progressive interference, lesion, or abnormality of the developing/immature brain. One clinical presentation is muscle spasticity, which leads to a significant impact on the individual's functionality and quality of life. Spasticity treatment is multidisciplinary and includes pharmacological and physical intervention; intrathecal baclofen shows a positive effect in severe spasticity and suboptimal response to oral drugs, while local injection of Botulinum toxin type A (BTXA) improves muscle tone, motion and pain.

OBJECTIVE:

The aim of this study was to evaluate the efficacy of the combined intrathecal baclofen infusion (ITB) - botulinum toxin treatment in the management of spasticity in CP.

METHODS:

8 patients with spastic tetraparesis were enrolled. All patients were treated with intrathecal Baclofen; in lower limbs, no spastic symptoms appeared, while marked spasticity was noted in upper limbs. We injected the right and left Biceps Brachial (BB) and Flexor Digitorum Superficialis (FDS) muscles with botulinum toxin type A. All patients underwent Myometric measurement, Ashworth Scale, Numerical Rating Scale, and Visual Analogic Scale evaluation before infiltration (T0), 30 days after injection (T1), 60 days after injection (T2), and 90 days after treatment (T3).

RESULTS:

All data demonstrated an improvement in spasticity, pain, quality of life, and self-care during the study, with p < 0.05. No side effects appeared.

CONCLUSION:

This study demonstrated the efficacy and safety of intrathecal baclofen infusion and botulinum toxin combined treatment in the management of spasticity, pain, quality of life, and selfcare in CP patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Baclofeno / Parálisis Cerebral / Toxinas Botulínicas Tipo A / Relajantes Musculares Centrales / Espasticidad Muscular Aspecto: Patient_preference Límite: Adolescent / Adult / Female / Humans / Male Idioma: En Revista: CNS Neurol Disord Drug Targets Asunto de la revista: NEUROLOGIA / TERAPIA POR MEDICAMENTOS Año: 2024 Tipo del documento: Article País de afiliación: Italia

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Baclofeno / Parálisis Cerebral / Toxinas Botulínicas Tipo A / Relajantes Musculares Centrales / Espasticidad Muscular Aspecto: Patient_preference Límite: Adolescent / Adult / Female / Humans / Male Idioma: En Revista: CNS Neurol Disord Drug Targets Asunto de la revista: NEUROLOGIA / TERAPIA POR MEDICAMENTOS Año: 2024 Tipo del documento: Article País de afiliación: Italia
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