Empty follicle syndrome following GnRH agonist stimulation, in a patient with PCOS treated with HCG rescue protocol, resulting in 3PN zygote formation: a case report.
JBRA Assist Reprod
; 28(2): 365-367, 2024 Jun 01.
Article
en En
| MEDLINE
| ID: mdl-38224578
ABSTRACT
Empty follicle syndrome is a rare condition characterized by failure to retrieve oocytes despite repeated careful aspiration of mature precursor follicles during controlled ovarian stimulation. This report presents a case of empty follicle syndrome in a patient with polycystic ovary syndrome using a gonadotropin-releasing hormone agonist as a trigger for final oocyte maturation. No oocytes were retrieved from the right ovary and the procedure was discontinued. The patient was administered an injection with 10,000 units of HCG and 3 oocytes were obtained after 24 hours. All oocytes were mature (MII); fertilization was performed with sperm from the patient's husband resulting in 3PN zygotes. The formation of 3PN zygotes from ICSI might be due to oocyte cytoplasmic disorders caused by long-term exposure to gonadotropins and increased duration of stimulation. Although our patient had false empty follicle syndrome and the hCG rescue protocol led to the retrieval of oocytes, the oocytes were not of good quality. As previously described, empty follicle syndrome is not a predictor of success in subsequent cycles. Our patient's next cycle was uneventful.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Inducción de la Ovulación
/
Síndrome del Ovario Poliquístico
/
Cigoto
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Hormona Liberadora de Gonadotropina
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Inyecciones de Esperma Intracitoplasmáticas
/
Gonadotropina Coriónica
Tipo de estudio:
Prognostic_studies
Límite:
Adult
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Female
/
Humans
Idioma:
En
Revista:
JBRA Assist Reprod
Año:
2024
Tipo del documento:
Article
País de afiliación:
Irán