Your browser doesn't support javascript.
loading
SARS-CoV-2 induces inflammation and intracranial infection through the olfactory epithelium-olfactory bulb pathway in non-human primates.
Shimizu, Shino; Nakayama, Misako; Nguyen, Cong Thanh; Ishigaki, Hirohito; Kitagawa, Yoshinori; Yasui, Fumihiko; Yagi, Yoshiki; Kusayanagi, Tomoe; Kohara, Michinori; Itoh, Yasushi; Tojima, Ichiro; Kouzaki, Hideaki; Shimizu, Takeshi.
Afiliación
  • Shimizu S; Department of Otorhinolaryngology-Head and Neck Surgery, Shiga University of Medical Science, Otsu, Shiga, Japan. Electronic address: sshino@belle.shiga-med.ac.jp.
  • Nakayama M; Division of Pathogenesis and Disease Regulation, Department of Pathology, Shiga University of Medical Science, Otsu, Japan.
  • Nguyen CT; Division of Pathogenesis and Disease Regulation, Department of Pathology, Shiga University of Medical Science, Otsu, Japan.
  • Ishigaki H; Division of Pathogenesis and Disease Regulation, Department of Pathology, Shiga University of Medical Science, Otsu, Japan.
  • Kitagawa Y; Division of Microbiology and Infectious Disease, Department of Pathology, Shiga University of Medical Science, Otsu, Japan.
  • Yasui F; Department of Microbiology and Cell Biology, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
  • Yagi Y; Nobelpharma Co., Ltd., Tokyo, Japan.
  • Kusayanagi T; Nobelpharma Co., Ltd., Tokyo, Japan.
  • Kohara M; Department of Microbiology and Cell Biology, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
  • Itoh Y; Division of Pathogenesis and Disease Regulation, Department of Pathology, Shiga University of Medical Science, Otsu, Japan.
  • Tojima I; Department of Otorhinolaryngology-Head and Neck Surgery, Shiga University of Medical Science, Otsu, Shiga, Japan.
  • Kouzaki H; Department of Otorhinolaryngology-Head and Neck Surgery, Shiga University of Medical Science, Otsu, Shiga, Japan.
  • Shimizu T; Department of Otorhinolaryngology-Head and Neck Surgery, Shiga University of Medical Science, Otsu, Shiga, Japan.
J Neuroimmunol ; 387: 578288, 2024 02 15.
Article en En | MEDLINE | ID: mdl-38237527
ABSTRACT
We examined the histopathological changes in the olfactory mucosa of cynomolgus and rhesus macaque models of SARS-CoV-2 infection. SARS-CoV-2 infection induced severe inflammatory changes in the olfactory mucosa. A major histocompatibility complex (MHC) class II molecule, HLA-DR was expressed in macrophage and supporting cells, and melanocytes were increased in olfactory mucosa. Supporting cells and olfactory neurons were infected, and SARS-CoV-2 N protein was detected in the axons of olfactory neurons and in olfactory bulbs. Viral RNA was detected in olfactory bulbs and brain tissues. The olfactory epithelium-olfactory bulb pathway may be important as a route for intracranial infection by SARS-CoV-2.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bulbo Olfatorio / COVID-19 Límite: Animals Idioma: En Revista: J Neuroimmunol Año: 2024 Tipo del documento: Article
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bulbo Olfatorio / COVID-19 Límite: Animals Idioma: En Revista: J Neuroimmunol Año: 2024 Tipo del documento: Article