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Reduced resting beat-to-beat blood pressure variability in females with relapsing-remitting multiple sclerosis.
Kissell, Claire E; Young, Benjamin E; Jarrard, Caitlin P; Huang, Mu; Allen, Dustin R; Okuda, Darin T; Smith, Scott A; Fadel, Paul J; Davis, Scott L.
Afiliación
  • Kissell CE; Department of Applied Physiology and Sport Management, Southern Methodist University, Dallas, TX, USA.
  • Young BE; Department of Applied Clinical Research, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
  • Jarrard CP; Department of Applied Clinical Research, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
  • Huang M; Office of Science, Medicine, and Health, American Heart Association, Dallas, TX, USA.
  • Allen DR; Department of Health Sciences, Boston University, Boston, Massachusetts, USA.
  • Okuda DT; Department of Neurology, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
  • Smith SA; Department of Applied Clinical Research, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
  • Fadel PJ; Department of Kinesiology, University of Texas at Arlington, Arlington, TX, USA.
  • Davis SL; Department of Applied Physiology and Sport Management, Southern Methodist University, Dallas, TX, USA; Department of Applied Clinical Research, The University of Texas Southwestern Medical Center, Dallas, TX, USA. Electronic address: sldavis@smu.edu.
Mult Scler Relat Disord ; 83: 105416, 2024 Mar.
Article en En | MEDLINE | ID: mdl-38244526
ABSTRACT

BACKGROUND:

Relapsing-remitting multiple sclerosis (RRMS) is a demyelinating disease of the central nervous system and cardiovascular autonomic dysfunction has been well documented in this population. The sympathetic nervous system contributes to beat-to-beat blood pressure regulation primarily by baroreflex control of the peripheral vasculature which may be impaired in females with RRMS. Even at rest, attenuated sympathetic control of vasomotor tone may result in large and frequent blood pressure excursions (i.e., greater blood pressure variability). Therefore, the primary purpose of this investigation was to test the following hypotheses; (1) females with RRMS have augmented beat-to-beat blood pressure variability compared to healthy controls and (2) reduced sympathetic baroreflex sensitivity in females with RRMS is related to augmented blood pressure variability.

METHODS:

Electrocardiogram and beat-to-beat blood pressure were continuously recorded during 8-10 min of supine rest in 26 females with clinically definite RRMS and 24 sex-, age- and BMI- matched healthy controls. Muscle sympathetic nerve activity (MSNA) was recorded in a subset of participants (MS, n = 15; CON, n = 14). Traditional statistical measurements of dispersions were used to index beat-to-beat blood pressure variability. Spontaneous sympathetic baroreflex sensitivity was quantified by sorting diastolic blood pressures into 3 mmHg bins and calculating MSNA burst incidence within each bin. Weighted linear regression was then used to account for the number of cardiac cycles in each bin and calculate slopes. Spontaneous cardiac baroreflex sensitivity was determined using the sequence method.

RESULTS:

Groups had similar resting mean arterial pressure (MAP), systolic blood pressure (SBP), diastolic blood pressure (DBP), MSNA burst frequency and MSNA burst incidence (All P > 0.05). The standard deviation and interquartile range of MAP, SBP and DBP were less in females with RRMS compared to healthy controls (All P < 0.05). There were no between groups differences in sympathetic baroreflex sensitivity or cardiac baroreflex sensitivity (Both P > 0.05) and baroreflex sensitivity measures were not related to any indices of blood pressure variability (Both P > 0.05).

CONCLUSION:

These data suggest that females with RRMS have reduced beat-to-beat blood pressure variability. However, this does not appear to be related to changes in sympathetic or cardiac baroreflex sensitivity.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esclerosis Múltiple Recurrente-Remitente / Hipertensión / Esclerosis Múltiple Límite: Female / Humans / Male Idioma: En Revista: Mult Scler Relat Disord Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esclerosis Múltiple Recurrente-Remitente / Hipertensión / Esclerosis Múltiple Límite: Female / Humans / Male Idioma: En Revista: Mult Scler Relat Disord Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos
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