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Interleukins in Platelet Biology: Unraveling the Complex Regulatory Network.
Huang, Miao; Wang, Long; Zhang, Qianhui; Zhou, Ling; Liao, Rui; Wu, Anguo; Wang, Xinle; Luo, Jiesi; Huang, Feihong; Zou, Wenjun; Wu, Jianming.
Afiliación
  • Huang M; State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
  • Wang L; Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou 646000, China.
  • Zhang Q; State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
  • Zhou L; Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou 646000, China.
  • Liao R; Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou 646000, China.
  • Wu A; Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou 646000, China.
  • Wang X; Department of Physiology, School of Basic Medical Sciences, Southwest Medical University, Luzhou 646000, China.
  • Luo J; Department of Physiology, School of Basic Medical Sciences, Southwest Medical University, Luzhou 646000, China.
  • Huang F; Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou 646000, China.
  • Zou W; State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
  • Wu J; Department of Physiology, School of Basic Medical Sciences, Southwest Medical University, Luzhou 646000, China.
Pharmaceuticals (Basel) ; 17(1)2024 Jan 13.
Article en En | MEDLINE | ID: mdl-38256942
ABSTRACT
Interleukins, a diverse family of cytokines produced by various cells, play crucial roles in immune responses, immunoregulation, and a wide range of physiological and pathological processes. In the context of megakaryopoiesis, thrombopoiesis, and platelet function, interleukins have emerged as key regulators, exerting significant influence on the development, maturation, and activity of megakaryocytes (MKs) and platelets. While the therapeutic potential of interleukins in platelet-related diseases has been recognized for decades, their clinical application has been hindered by limitations in basic research and challenges in drug development. Recent advancements in understanding the molecular mechanisms of interleukins and their interactions with MKs and platelets, coupled with breakthroughs in cytokine engineering, have revitalized the field of interleukin-based therapeutics. These breakthroughs have paved the way for the development of more effective and specific interleukin-based therapies for the treatment of platelet disorders. This review provides a comprehensive overview of the effects of interleukins on megakaryopoiesis, thrombopoiesis, and platelet function. It highlights the potential clinical applications of interleukins in regulating megakaryopoiesis and platelet function and discusses the latest bioengineering technologies that could improve the pharmacokinetic properties of interleukins. By synthesizing the current knowledge in this field, this review aims to provide valuable insights for future research into the clinical application of interleukins in platelet-related diseases.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Pharmaceuticals (Basel) Año: 2024 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Pharmaceuticals (Basel) Año: 2024 Tipo del documento: Article País de afiliación: China
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