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Syntheses of Cannabinoid Metabolites: Ajulemic Acid and HU-210.
Shao, Wenbin; Liao, Pingyong; Zhang, Xiaoyan; Fan, Binbin; Chen, Ruijia; Chen, Xilong; Zhao, Xuejun; Liu, Wenbin.
Afiliación
  • Shao W; Shanghai Key Laboratory of Crime Scene Evidence, Shanghai Research Institute of Criminal Science and Technology, Shanghai 200072, China.
  • Liao P; Shanghai Yuansi Standard Science and Technology Co., Ltd., Shanghai 200072, China.
  • Zhang X; Shanghai Key Laboratory of Crime Scene Evidence, Shanghai Research Institute of Criminal Science and Technology, Shanghai 200072, China.
  • Fan B; Shanghai Yuansi Standard Science and Technology Co., Ltd., Shanghai 200072, China.
  • Chen R; State Key Laboratory of Bio-Fibers and Eco-Textiles, Institute of Marine Biobased Materials, Collage of Materials Science and Engineering, Qingdao University, Qingdao 266071, China.
  • Chen X; State Key Laboratory of Bio-Fibers and Eco-Textiles, Institute of Marine Biobased Materials, Collage of Materials Science and Engineering, Qingdao University, Qingdao 266071, China.
  • Zhao X; Shanghai Key Laboratory of Crime Scene Evidence, Shanghai Research Institute of Criminal Science and Technology, Shanghai 200072, China.
  • Liu W; Shanghai Yuansi Standard Science and Technology Co., Ltd., Shanghai 200072, China.
Molecules ; 29(2)2024 Jan 21.
Article en En | MEDLINE | ID: mdl-38276604
ABSTRACT
Cannabinoid metabolites have been reported to be more potent than their parent compounds. Among them, ajulemic acid (AJA) is a side-chain analog of Δ9-THC-11-oic acid, which would be a good template structure for the discovery of more potent analogues. Herein, we optimized the key allylic oxidation step to introduce the C-11 hydroxy group with a high yield. A series of compounds was prepared with this condition applied including HU-210, 11-nor-Δ8-tetrahydrocannabinol (THC)-carboxylic acid and Δ9-THC-carboxylic acid.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dronabinol / Cannabinoides Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dronabinol / Cannabinoides Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China