Genome-edited rabbits: Unleashing the potential of a promising experimental animal model across diverse diseases.
Zool Res
; 45(2): 253-262, 2024 Mar 18.
Article
en En
| MEDLINE
| ID: mdl-38287906
ABSTRACT
Animal models are extensively used in all aspects of biomedical research, with substantial contributions to our understanding of diseases, the development of pharmaceuticals, and the exploration of gene functions. The field of genome modification in rabbits has progressed slowly. However, recent advancements, particularly in CRISPR/Cas9-related technologies, have catalyzed the successful development of various genome-edited rabbit models to mimic diverse diseases, including cardiovascular disorders, immunodeficiencies, aging-related ailments, neurological diseases, and ophthalmic pathologies. These models hold great promise in advancing biomedical research due to their closer physiological and biochemical resemblance to humans compared to mice. This review aims to summarize the novel gene-editing approaches currently available for rabbits and present the applications and prospects of such models in biomedicine, underscoring their impact and future potential in translational medicine.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
1_ASSA2030
Problema de salud:
1_geracao_evidencia_conhecimento
Asunto principal:
Drogas Veterinarias
/
Investigación Biomédica
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Zool Res
Año:
2024
Tipo del documento:
Article
País de afiliación:
China