Endotypes of occupational asthma.
Curr Opin Allergy Clin Immunol
; 24(2): 58-63, 2024 04 01.
Article
en En
| MEDLINE
| ID: mdl-38295127
ABSTRACT
PURPOSE OF REVIEW To describe recent findings in endotyping occupational asthma by addressing the role of specific biomarkers. RECENT FINDINGS:
Studies on occupational asthma endotypes have focused on immune and inflammatory patterns associated with different occupational exposures to sensitizers or irritants.Sputum neutrophilia has been found in 58.5% patients with occupational asthma caused by high molecular weight (HMW) agents, and work-related dysphonia in patients with occupational asthma was described as associated with sputum neutrophilia too. Neutrophils have been associated also with irritant-induced asthma. The measurement of specific IgE has been confirmed as a valuable diagnostic tool in occupational asthma caused by HMW agents, on the contrary, for most low-molecular-weight agents, the presence of specific IgE has been proven in a small subset of affected workers. Fractional exhaled nitric oxide has been confirmed as a marker of type 2 (T2) inflammation in occupational asthma, mostly when induced by HMW agents (e.g. flour), and it has proved to be more sensitive than spirometry in measuring the efficacy of an intervention.MicroRNA-155 has been shown to contribute to airway inflammation in occupational asthma induced by toluene diisocyanate.SUMMARY:
Occupational asthma is heterogeneous, thus monitoring multiple biomarkers is crucial to understand, which inflammatory responses are prevalent.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
12_ODS3_hazardous_contamination
Problema de salud:
12_occupational_exposures
Asunto principal:
Exposición Profesional
/
MicroARNs
/
Asma Ocupacional
/
Enfermedades Profesionales
Límite:
Humans
Idioma:
En
Revista:
Curr Opin Allergy Clin Immunol
Asunto de la revista:
ALERGIA E IMUNOLOGIA
Año:
2024
Tipo del documento:
Article
País de afiliación:
Italia