Ethambutol and its ophthalmic effects; is screening and collaboration the new way forward?
Indian J Tuberc
; 71(1): 30-34, 2024 Jan.
Article
en En
| MEDLINE
| ID: mdl-38296388
ABSTRACT
AIM:
To screen patients on ethambutol and evaluate its role on visual functions and toxic optic neuropathy. SETTING ANDDESIGN:
Retrospective, observational single tertiary centre cohort of 80 patients. METHODS ANDMATERIAL:
A total of 69 from the initial 80 patients with visual complaints were categorised into two groups A and B; ongoing anti-tubercular therapy with ethambutol and having stopped ethambutol for greater than six months respectively. All patients underwent vision (V) testing on ETDRS chart and anterior and posterior segment evaluation. Additionally, patients in group A recorded color vision (CV) on Ishihara chart and visual evoked potential (VEP). STATISTICAL ANALYSIS USED P value was calculated using Chi square test (SPSS ver. 20).RESULTS:
Out of 69 patients in our study, 58 (84.05%) patients recorded reduced visual acuity. The mean visual acuity was 0.58 logMAR units. 33 out of our 58 (57%) patients with reduced visual acuity showed normal optic discs while 25 out of 58 (43%) showed altered optic discs. In group B, 14 out of 32 patients with vision of less than 20/20 also had optic disc pallor (p = 0.02). 12 out of 15 patients in group A recorded an altered color vision and also had a vision of less than 20/20 (p = 0.023). 15 patients who recorded altered VEP also had vision of less than 20/20 (p = 0.037).CONCLUSION:
Visual acuity, color vision and vep are sensitive and sustainable tools which can be implemented in regular screening. Ethambutol toxicity is a real problem and a collaborative approach is necessary to establish screening protocols and prevent ethambutol induced toxic optic neuropathy.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
3_ND
Problema de salud:
3_neglected_diseases
/
3_tuberculosis
Asunto principal:
Enfermedades del Nervio Óptico
/
Etambutol
Tipo de estudio:
Diagnostic_studies
/
Guideline
/
Observational_studies
/
Screening_studies
Límite:
Humans
Idioma:
En
Revista:
Indian J Tuberc
Año:
2024
Tipo del documento:
Article
País de afiliación:
India