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Ovarian Suppression: Early Menopause, Late Effects.
Goldberg, Chaya; Greenberg, Megan R; Noveihed, Alexandra; Agrawal, Laila; Omene, Coral; Toppmeyer, Deborah; George, Mridula A.
Afiliación
  • Goldberg C; Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.
  • Greenberg MR; Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.
  • Noveihed A; Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.
  • Agrawal L; Norton Cancer Institute, Louisville, KY, USA.
  • Omene C; Rutgers Cancer Institute of New Jersey, Rutgers, 195 Little Albany Street, New Brunswick, NJ, 08901, USA.
  • Toppmeyer D; Rutgers Cancer Institute of New Jersey, Rutgers, 195 Little Albany Street, New Brunswick, NJ, 08901, USA.
  • George MA; Rutgers Cancer Institute of New Jersey, Rutgers, 195 Little Albany Street, New Brunswick, NJ, 08901, USA. mridula@cinj.rutgers.edu.
Curr Oncol Rep ; 26(5): 427-438, 2024 05.
Article en En | MEDLINE | ID: mdl-38305992
ABSTRACT
PURPOSE OF REVIEW Pre-menopausal women diagnosed with hormone receptor (HR) breast cancer are candidates for prolonged hypoestrogenism to improve cancer outcomes. However, the disease benefit eclipses the toxicities associated with ovarian function suppression (OFS), which are often under-reported. RECENT

FINDINGS:

Increased risk of mortality from cardiovascular disease, bone disorders, and metabolic disorders is well reported in women with no history of cancer, after surgical oophorectomy or premature ovarian failure. Vasomotor symptoms, urogenital atrophy, weight gain, sexual dysfunction, cognitive decline, and sleep disturbances contribute to the increased non-compliance associated with OFS, especially in younger women. Balancing the toxicities of prolonged OFS with its benefits should be critically analyzed by providers when making recommendations for their patients. Supportive care to manage multi-system toxicities and to counteract the long-term impact on all-cause mortality should be emphasized by every cancer program. Future studies with OFS should incorporate patient outcomes and strategies for symptom management in addition to focusing on improving disease outcomes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 6_ODS3_enfermedades_notrasmisibles Problema de salud: 6_ovary_cancer Asunto principal: Neoplasias de la Mama / Menopausia Prematura Tipo de estudio: Guideline Límite: Female / Humans Idioma: En Revista: Curr Oncol Rep Asunto de la revista: NEOPLASIAS Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 6_ODS3_enfermedades_notrasmisibles Problema de salud: 6_ovary_cancer Asunto principal: Neoplasias de la Mama / Menopausia Prematura Tipo de estudio: Guideline Límite: Female / Humans Idioma: En Revista: Curr Oncol Rep Asunto de la revista: NEOPLASIAS Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos
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