Chalcone-Based Synthesis of Tetrahydropyridazines via Cloke-Wilson-Type Rearrangement-Involved Tandem Reaction between Cyclopropyl Ketones and Hydrazines.

Meng, Yingfen; Gu, Jiayi; Xin, Meixiu; Jiang, Yi; Du, Zhibo; Lu, Guoqing; Jiang, Jiayao; Chan, Albert S C; Ke, Zhuofeng; Zou, Yong

Meng, Yingfen; Gu, Jiayi; Xin, Meixiu; Jiang, Yi; Du, Zhibo; Lu, Guoqing; Jiang, Jiayao; Chan, Albert S C; Ke, Zhuofeng; Zou, Yong.

Afiliación

Meng Y; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China.
Gu J; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China.
Xin M; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China.
Jiang Y; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China.
Du Z; Zhongshan WanHan Pharmceutical Company, Ltd., Zhongshan 528451, People's Republic of China.
Lu G; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China.
Jiang J; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China.
Chan ASC; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China.
Ke Z; School of Materials Science & Engineering, PCFM Lab, Sun Yat-sen University, Guangzhou 510006, People's Republic of China.
Zou Y; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China.

J Org Chem ; 89(4): 2726-2740, 2024 Feb 16.

Article en En | MEDLINE | ID: mdl-38307838

ABSTRACT

ABSTRACT

A facile and efficient approach for the synthesis of multisubstituted tetrahydropyridazines starting from cyclopropyl ketones and hydrazines has been developed. The transformation is chalcone-based and takes place via a Cloke-Wilson-type rearrangement-involved tandem reaction catalyzed by TfOH in HFIP.

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Org Chem Año: 2024 Tipo del documento: Article