Astrocyte Regulation of Synapse Formation, Maturation, and Elimination.
Cold Spring Harb Perspect Biol
; 16(8)2024 Aug 01.
Article
en En
| MEDLINE
| ID: mdl-38346858
ABSTRACT
Astrocytes play an integral role in the development, maturation, and refinement of neuronal circuits. Astrocytes secrete proteins and lipids that instruct the formation of new synapses and induce the maturation of existing synapses. Through contact-mediated signaling, astrocytes can regulate the formation and state of synapses within their domain. Through phagocytosis, astrocytes participate in the elimination of excess synaptic connections. In this work, we will review key findings on the molecular mechanisms of astrocyte-synapse interaction with a focus on astrocyte-secreted factors, contact-mediated mechanisms, and synapse elimination. We will discuss this in the context of typical brain development and maintenance, as well as consider the consequences of dysfunction in these pathways in neurological disorders, highlighting a role for astrocytes in health and disease.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Sinapsis
/
Astrocitos
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Cold Spring Harb Perspect Biol
Asunto de la revista:
BIOLOGIA
Año:
2024
Tipo del documento:
Article