Therapeutic success and failure in using miltefosine to treat dogs naturally infected with Leishmania infantum.
Rev Bras Parasitol Vet
; 33(1): e015023, 2024.
Article
en En
| MEDLINE
| ID: mdl-38359300
ABSTRACT
In urban environments, domestic dogs (Canis familiaris) are a major reservoir for the parasite Leishmania infantum. Miltefosine has been used as the standard treatment for canine visceral leishmaniasis in Brazil. However, therapeutic failures have been reported. In the present study, two dogs (CG03 and CG06) with a diagnosis of infection by L. infantum underwent two cycles of treatment with miltefosine (Milteforan™ - Virbac®). Analyses showed increases in the parasite load of both CG03 and CG06, even after treatment. The clinical score of CG03 dropped from 1 to 0 (after one round of treatment), such that this dog became asymptomatic. CG06 showed clinical worsening, such that its score increased from 1 to 2. After the second therapeutic round, the parasite load in CG03 was found to have decreased, but it was still higher than before drug treatment even though this dog was physically asymptomatic. There was no decrease in the parasite load in CG06 and there was clinical worsening. The clinical response of these dogs to the treatment differed, but the parasite load remained high in both cases, which poses a risk to public health, making it essential take measures to prevent the sandfly vector from accessing the dog.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
3_ND
Problema de salud:
3_zoonosis
Asunto principal:
Fosforilcolina
/
Leishmania infantum
/
Enfermedades de los Perros
/
Leishmaniasis Visceral
Límite:
Animals
Idioma:
En
Revista:
Rev Bras Parasitol Vet
Asunto de la revista:
MEDICINA VETERINARIA
/
PARASITOLOGIA
Año:
2024
Tipo del documento:
Article
País de afiliación:
Brasil