Impact of DEHP exposure on female reproductive health: Insights into uterine effects.
Environ Toxicol Pharmacol
; 107: 104391, 2024 Apr.
Article
en En
| MEDLINE
| ID: mdl-38367918
ABSTRACT
Several endocrine disrupting compounds released from plastics, including polyfluoroalkyl substances, bisphenols, flame retardants, phthalates and others, are of great concern to human health due to their high toxicity. This review discusses the effects of di-(2-ethylhexyl) phthalate (DEHP), the most common member of the phthalate family, on female reproduction. In vitro and in vivo studies link DEHP exposure to impaired hypothalamic-pituitary-ovarian s (HPO) axis function, alteration of steroid-hormone levels and dysregulation of their receptors, and changes in uterine morphophysiology. In addition, high urinary DEPH levels have been associated with several reproductive disorders in women, including endometriosis, fibromyoma, fetal growth restriction and pregnancy loss. These data suggest that DEHP may be involved in the pathophysiology of various female reproductive diseases. Therefore, exposure to these compounds should be considered a concern in clinician surveillance practices for women at reproductive age and should be regulated to protect their health and that of their progeny.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ácidos Ftálicos
/
Dietilhexil Ftalato
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Disruptores Endocrinos
Límite:
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
Environ Toxicol Pharmacol
/
Environ. toxicol. pharmacol
/
Environmental toxicology and pharmacology
Año:
2024
Tipo del documento:
Article