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Apelin-13 alleviates osteoclast formation and osteolysis through Nrf2-pyroptosis pathway.
Yin, Zhaoyang; Cheng, Qinghua; Wang, Chao; Hu, Qin; Yin, Jian; Wang, Bin.
Afiliación
  • Yin Z; Department of Orthopedics, The Affiliated Lianyungang Hospital of Xuzhou Medical University (The First People's Hospital of Lianyungang), Lianyungang, China.
  • Cheng Q; Department of Orthopedics, Nanjing Lishui People's Hospital, Zhongda Hospital Lishui Branch, Southeast University, Nanjing, China.
  • Wang C; Department of Orthopedics, The Affiliated Jiangning Hospital with Nanjing Medical University, Nanjing, China.
  • Hu Q; Department of Orthopedics, The Affiliated Jiangning Hospital with Nanjing Medical University, Nanjing, China.
  • Yin J; Department of Orthopedics, The Affiliated Jiangning Hospital with Nanjing Medical University, Nanjing, China.
  • Wang B; Department of Orthopedics, The Affiliated Jiangning Hospital with Nanjing Medical University, Nanjing, China.
Microsc Res Tech ; 87(6): 1348-1358, 2024 Jun.
Article en En | MEDLINE | ID: mdl-38380581
ABSTRACT
Wear particle-induced periprosthetic osteolysis is the key to aseptic loosening after artificial joint replacement. Osteoclastogenesis plays a central role in this process. Apelin-13 is a member of the adipokine family with anti-inflammatory effects. Here, we report that apelin-13 alleviates RANKL-mediated osteoclast differentiation and titanium particle-induced osteolysis in mouse calvaria. Mechanistically, apelin-13 inhibits NLRP3 inflammasome-mediated pyroptosis by activating the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway. In summary, apelin-13 is expected to be a potential drug for relieving aseptic osteolysis. RESEARCH HIGHLIGHTS This study reveals the molecular mechanism by which apelin-13 inhibits NLRP3 inflammasome activation and pyroptosis by promoting Nrf2. This study confirms that apelin-13 alleviates osteoclast activation by inhibiting pyroptosis. In vivo studies further confirmed that apelin-13 alleviated mouse skull osteolysis by inhibiting the activation of NLRP3 inflammasome.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Osteoclastos / Osteólisis / Péptidos y Proteínas de Señalización Intercelular Límite: Animals Idioma: En Revista: Microsc Res Tech Asunto de la revista: DIAGNOSTICO POR IMAGEM Año: 2024 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Osteoclastos / Osteólisis / Péptidos y Proteínas de Señalización Intercelular Límite: Animals Idioma: En Revista: Microsc Res Tech Asunto de la revista: DIAGNOSTICO POR IMAGEM Año: 2024 Tipo del documento: Article País de afiliación: China
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