High-Dose Intravenous Immunoglobulin to Treat Anti-Thymocyte Globulin Induction-Related BK Virus and Cytomegalovirus Infection in Patients with ABO-Incompatible Kidney Transplantation.
Transplant Proc
; 56(3): 726-728, 2024 Apr.
Article
en En
| MEDLINE
| ID: mdl-38388292
ABSTRACT
BACKGROUND:
ABO-incompatible (ABOi) transplantation is a novel method transplantation method that carries a heightened risk of infection caused by the use of high immunosuppressant doses. This elevated risk is particularly concerning for viral infections, such as cytomegalovirus (CMV) and the BK virus (BKV) increases. Herein, we present a case where high-dose intravenous immunoglobulin (IVIG) was effective in treating viral infections after transplantation.METHODS:
A 41-year-old man underwent an ABOi transplantation. The initial isoagglutinin titer was 132. The patient received 200 mg of rituximab, and 3 rounds of plasmapheresis were performed. Subsequently, renal function remained normal; however, 7 months later, the renal function declined, and BK nephropathy and CMV infection were diagnosed through biopsy and serologic tests. The FK level was reduced, and mycophenolate mofetil was discontinued. Although ciprofloxacin and leflunomide were administered, their effects were minimal. Therefore, high-dose IVIG (1 g/kg) was administered 5 times over 5 weeks, which led to a reduction in BK viral load and CMV infectivity in the serum.CONCLUSIONS:
High-dose IVIG may serve as a promising alternative treatment to mitigate early transplant rejection and BKV and CMV infections.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Infecciones Tumorales por Virus
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Trasplante de Riñón
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Inmunoglobulinas Intravenosas
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Virus BK
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Infecciones por Citomegalovirus
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Infecciones por Polyomavirus
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Suero Antilinfocítico
Límite:
Adult
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Humans
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Male
Idioma:
En
Revista:
Transplant Proc
Año:
2024
Tipo del documento:
Article
País de afiliación:
Corea del Sur