Association between pulp and periapical disease with type 2 diabetes: A bidirectional Mendelian randomization.
Int Endod J
; 57(5): 566-575, 2024 May.
Article
en En
| MEDLINE
| ID: mdl-38411530
ABSTRACT
AIM:
This current Mendelian randomization (MR) study aims to comprehensively explore the potential bidirectional link between pulp and periapical disease (PAP) with type 2 diabetes mellitus (T2DM).METHODOLOGY:
Summary level data of European-based population genome-wide association studies (GWASs) were employed to undertake this MR study. With the selection of single nucleotide polymorphisms (SNPs) as the instrumental variable, the radial inverse-variance weighted (radial IVW) method with modified second-order weights was applied as the primary method. Additionally, a range of sensitivity analyses were conducted to investigate pleiotropy. Results from different sources of outcome were pooled by meta-analysis with the fixed model.RESULTS:
The results of this MR analysis did not suggest a significant impact of pulp and periapical disease on type 2 diabetes (combined OR = 1.04, 95% CI 1.00-1.07, p = .033) and vice versa (OR = 1.04, 95% CI 0.96-1.14, p = .329). No significant pleiotropy was detected in the final model after the removal of outliers, demonstrating the reliability of the results in our primary analysis.CONCLUSIONS:
With the limitations inherent in the present MR study, there is no significant evidence in either direction to suggest a causal association between pulp and periapical disease and type 2 diabetes mellitus.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Enfermedades Periapicales
/
Enfermedades de la Pulpa Dental
/
Diabetes Mellitus Tipo 2
Límite:
Humans
Idioma:
En
Revista:
Int Endod J
Año:
2024
Tipo del documento:
Article
País de afiliación:
China