Current and Emerging Antiviral Agents in the Prevention and Treatment of Cytomegalovirus in Pediatric Transplant Recipients.
J Pediatric Infect Dis Soc
; 13(Supplement_1): S14-S21, 2024 Feb 28.
Article
en En
| MEDLINE
| ID: mdl-38417084
ABSTRACT
Despite current prophylaxis regimens, cytomegalovirus (CMV) is common in hematopoietic cell transplantation (HCT) and solid organ transplantation (SOT) and remains a significant cause of morbidity and mortality. Newer antiviral medications are reshaping the landscape for prevention and treatment of CMV DNAemia, infection, and disease. Letermovir is approved for CMV prevention in adult HCT patients and is attractive due to the absence of marrow suppression seen with ganciclovir/valganciclovir. Letermovir should not be routinely used for CMV treatment due to its low threshold for resistance. Maribavir is approved for the treatment of refractory or resistant CMV disease in HCT and SOT recipients ≥12 years of age, though it has no current role in CMV prevention. More research is needed to fully elucidate the roles, efficacy, and safety of these newer agents in prevention and treatment of CMV in pediatric transplant recipients.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Quinazolinas
/
Infecciones por Citomegalovirus
/
Trasplante de Células Madre Hematopoyéticas
/
Acetatos
Límite:
Adult
/
Child
/
Humans
Idioma:
En
Revista:
J Pediatric Infect Dis Soc
Año:
2024
Tipo del documento:
Article
País de afiliación:
Estados Unidos