Biological treatment in severe psoriasis: Influence on peripheral blood dendritic cells.
Scand J Immunol
; 98(6): e13321, 2023 Dec.
Article
en En
| MEDLINE
| ID: mdl-38441394
ABSTRACT
In-depth immunophenotyping by flow cytometry of peripheral blood dendritic cell (DC) populations of psoriasis vulgaris without (PsO; N = 23) or with psoriatic arthritis (PsA; N = 15), before (T1) and after 12 months (T2) therapy with the anti-TNF drugs infliximab, etanercept, the anti-IL-17A secukinumab and the anti-IL12/IL-23 ustekinumab. Compared to healthy donors (N = 38), patients with PsA displayed lower frequencies of dendritic cell subsets pDC, cDC1 and cDC2, which were normalized following treatment except pDC. In contrast, patients with PsO only displayed lower frequencies of pDC which were normalized following treatment. Figure created with BioRender.com.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Psoriasis
/
Artritis Psoriásica
Límite:
Humans
Idioma:
En
Revista:
Scand J Immunol
Año:
2023
Tipo del documento:
Article
País de afiliación:
Noruega