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International consensus guidelines for the definition, detection, and interpretation of autophagy-dependent ferroptosis.
Chen, Xin; Tsvetkov, Andrey S; Shen, Han-Ming; Isidoro, Ciro; Ktistakis, Nicholas T; Linkermann, Andreas; Koopman, Werner J H; Simon, Hans-Uwe; Galluzzi, Lorenzo; Luo, Shouqing; Xu, Daqian; Gu, Wei; Peulen, Olivier; Cai, Qian; Rubinsztein, David C; Chi, Jen-Tsan; Zhang, Donna D; Li, Changfeng; Toyokuni, Shinya; Liu, Jinbao; Roh, Jong-Lyel; Dai, Enyong; Juhasz, Gabor; Liu, Wei; Zhang, Jianhua; Yang, Minghua; Liu, Jiao; Zhu, Ling-Qiang; Zou, Weiping; Piacentini, Mauro; Ding, Wen-Xing; Yue, Zhenyu; Xie, Yangchun; Petersen, Morten; Gewirtz, David A; Mandell, Michael A; Chu, Charleen T; Sinha, Debasish; Eftekharpour, Eftekhar; Zhivotovsky, Boris; Besteiro, Sébastien; Gabrilovich, Dmitry I; Kim, Do-Hyung; Kagan, Valerian E; Bayir, Hülya; Chen, Guang-Chao; Ayton, Scott; Lünemann, Jan D; Komatsu, Masaaki; Krautwald, Stefan.
Afiliación
  • Chen X; Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, China.
  • Tsvetkov AS; Department of Neurology, The University of Texas McGovern Medical School at Houston, Houston, TX, USA.
  • Shen HM; Department of Biomedical Sciences, Faculty of Health Sciences, University of Macau, Macau, China.
  • Isidoro C; Department of Health Sciences, University of Piemonte Orientale, Novara, Italy.
  • Ktistakis NT; Babraham Institute, Cambridge, UK.
  • Linkermann A; Division of Nephrology, Department of Internal Medicine 3, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Germany.
  • Koopman WJH; Division of Nephrology, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA.
  • Simon HU; Department of Pediatrics, Radboud Center for Mitochondrial Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.
  • Galluzzi L; Human and Animal Physiology, Wageningen University, Wageningen, The Netherlands.
  • Luo S; Institute of Pharmacology, University of Bern, Bern, Switzerland.
  • Xu D; Institute of Biochemistry, Brandenburg Medical School, Neuruppin, Germany.
  • Gu W; Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA.
  • Peulen O; Sandra and Edward Meyer Cancer Center, New York, NY, USA.
  • Cai Q; Caryl and Israel Englander Institute for Precision Medicine, New York, NY, USA.
  • Rubinsztein DC; Peninsula Medical School, University of Plymouth, Plymouth, UK.
  • Chi JT; Zhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Institute of Translational Medicine, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, China.
  • Zhang DD; Institute for Cancer Genetics, and Department of Pathology and Cell Biology, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY, USA.
  • Li C; Metastasis Research Laboratory, GIGA Cancer-University of Liège, Liège, Belgium.
  • Toyokuni S; Department of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.
  • Liu J; Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.
  • Roh JL; UK Dementia Research Institute, University of Cambridge, Cambridge, UK.
  • Dai E; Department of Molecular Genetics and Microbiology, Duke University, Durham, NC, USA.
  • Juhasz G; Pharmacology and Toxicology, R. Ken Coit College of Pharmacy, University of Arizona, Tucson, AZ, USA.
  • Liu W; Department of Endoscopy Center, China-Japan Union Hospital of Jilin University, Changchun, China.
  • Zhang J; Department of Pathology and Biological Response, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Yang M; Center for Low-temperature Plasma Sciences, Nagoya University, Nagoya, Japan.
  • Liu J; Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation, State Key Laboratory of Respiratory Disease, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, Chi
  • Zhu LQ; Department of Otorhinolaryngology-Head and Neck Surgery, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea.
  • Zou W; The Second Department of Hematology and Oncology, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China.
  • Piacentini M; Biological Research Center, Institute of Genetics, Szeged, Hungary.
  • Ding WX; Department of Anatomy, Cell and Developmental Biology, Eotvos Lorand University, Budapest, Hungary.
  • Yue Z; Department of Orthopedics, Changzheng Hospital, Second Affiliated Hospital of Naval Medical University, Shanghai, China.
  • Xie Y; Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA.
  • Petersen M; Department of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
  • Gewirtz DA; Hunan Clinical Research Center of Pediatric Cancer, Changsha, China.
  • Mandell MA; DAMP Laboratory, Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
  • Chu CT; Department of Pathophysiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Sinha D; Departments of Surgery and Pathology, University of Michigan Medical School, Ann Arbor, USA.
  • Eftekharpour E; Department of Biology, University of Rome "Tor Vergata", Rome, Italy.
  • Zhivotovsky B; National Institute for Infectious Diseases IRCCS "Lazzaro Spallanzani", Rome, Italy.
  • Besteiro S; Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, Kansas City, KS, USA.
  • Gabrilovich DI; Department of Neurology, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Kim DH; Department of Oncology, Central South University, Changsha, Hunan, China.
  • Kagan VE; Functional genomics, Department of Biology, Copenhagen University, Denmark.
  • Bayir H; Department of Pharmacology and Toxicology, Virginia Commonwealth University, Massey Cancer Center, Richmond, VA, USA.
  • Chen GC; Department of Molecular Genetics and Microbiology, University of New Mexico, Albuquerque, USA.
  • Ayton S; Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  • Lünemann JD; Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA, USA; Wilmer Eye lnstitute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Komatsu M; Department of Physiology and Pathophysiology, University of Manitoba, Winnipeg, Canada.
  • Krautwald S; Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer, Villejuif, France; Gustave Roussy Cancer, Villejuif, France.
Autophagy ; 20(6): 1213-1246, 2024 Jun.
Article en En | MEDLINE | ID: mdl-38442890
ABSTRACT
Macroautophagy/autophagy is a complex degradation process with a dual role in cell death that is influenced by the cell types that are involved and the stressors they are exposed to. Ferroptosis is an iron-dependent oxidative form of cell death characterized by unrestricted lipid peroxidation in the context of heterogeneous and plastic mechanisms. Recent studies have shed light on the involvement of specific types of autophagy (e.g. ferritinophagy, lipophagy, and clockophagy) in initiating or executing ferroptotic cell death through the selective degradation of anti-injury proteins or organelles. Conversely, other forms of selective autophagy (e.g. reticulophagy and lysophagy) enhance the cellular defense against ferroptotic damage. Dysregulated autophagy-dependent ferroptosis has implications for a diverse range of pathological conditions. This review aims to present an updated definition of autophagy-dependent ferroptosis, discuss influential substrates and receptors, outline experimental methods, and propose guidelines for interpreting the results.Abbreviation 3-MA3-methyladenine; 4HNE 4-hydroxynonenal; ACD accidentalcell death; ADF autophagy-dependentferroptosis; ARE antioxidant response element; BH2dihydrobiopterin; BH4 tetrahydrobiopterin; BMDMs bonemarrow-derived macrophages; CMA chaperone-mediated autophagy; CQchloroquine; DAMPs danger/damage-associated molecular patterns; EMT,epithelial-mesenchymal transition; EPR electronparamagnetic resonance; ER, endoplasmic reticulum; FRET Försterresonance energy transfer; GFP green fluorescent protein;GSH glutathione;IF immunofluorescence; IHC immunohistochemistry; IOP, intraocularpressure; IRI ischemia-reperfusion injury; LAA linoleamide alkyne;MDA malondialdehyde; PGSK Phen Green™ SK;RCD regulatedcell death; PUFAs polyunsaturated fatty acids; RFP red fluorescentprotein;ROS reactive oxygen species; TBA thiobarbituricacid; TBARS thiobarbituric acid reactive substances; TEMtransmission electron microscopy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Autofagia / Ferroptosis Límite: Animals / Humans Idioma: En Revista: Autophagy Año: 2024 Tipo del documento: Article País de afiliación: China
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Autofagia / Ferroptosis Límite: Animals / Humans Idioma: En Revista: Autophagy Año: 2024 Tipo del documento: Article País de afiliación: China