Acrobatic training prevents motor deficits and neuronal loss in male and female rats following chronic cerebral hypoperfusion.
Behav Brain Res
; 465: 114941, 2024 May 08.
Article
en En
| MEDLINE
| ID: mdl-38447760
ABSTRACT
BACKGROUND:
Chronic cerebral hypoperfusion in vascular dementia leads to memory and motor deficits; Physical exercise improves these aspects and promotes neuroprotection. Sexual dimorphism may significantly influence both ischemic and exercise outcomes.AIMS:
The aim of this study was to investigate the effects of 2VO (Two-Vessel occlusion) and the acrobatic training on motor function, functional performance, and tissue loss in male and female rats.METHODS:
Male and female rats were randomly divided into 4 groups sham acrobatic, sham sedentary, 2VO acrobatic and 2VO sedentary. After 45 days of 2VO surgery, the animals received 4 weeks of acrobatic training. At the end, open field, beam balance and horizontal ladder tests were performed. Brain samples were taken for histological and morphological evaluation.RESULTS:
Spontaneous motor activity in the open field was not affected by 2VO, on the other hand, an impairment in forelimb placement was observed after 2VO and acrobatic training prevented errors and improved hindlimb placement. Neuronal loss was found in the motor cortex and striatum after 2VO, especially in females, which was prevented by acrobatic training.CONCLUSION:
Mild motor damage was found in animals after 2VO when refined movement was evaluated, probably associated to neuronal death in the motor cortex and striatum. The acrobatic exercise showed a neuroprotective effect, promoting neuronal survival and attenuating the motor deficit.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
6_ODS3_enfermedades_notrasmisibles
Problema de salud:
6_alzheimer_other_dementias
/
6_cardiovascular_diseases
/
6_cerebrovascular_disease
/
6_mental_health_behavioral_disorders
Asunto principal:
Demencia Vascular
/
Isquemia Encefálica
/
Corteza Motora
Límite:
Animals
Idioma:
En
Revista:
Behav Brain Res
Año:
2024
Tipo del documento:
Article