Structurally diverse phthalides from fibrous roots of Ligusticum chuanxiong Hort. and their biological activities.
Fitoterapia
; 175: 105882, 2024 Jun.
Article
en En
| MEDLINE
| ID: mdl-38452906
ABSTRACT
Falonolide A (1) and B (2), two novel polyyne hybrid phthalides resulting from unprecedented carbon skeleton polymerized by Z-ligustilide and falcarindiol, along with six new related phthalides (3-8), were isolated from Ligusticum chuanxiong Hort. Their structures were elucidated by spectroscopic analysis, computer-assisted structure elucidation (CASE) analysis, DP4+ probability analysis and electronic circular dichroism (ECD) calculations. A plausible biosynthetic pathway for 1-8 was proposed, and the production mechanism of 2 was revealed by density functional theory (DFT) method. Compounds 4 and 6 exhibited significant vasodilatory activity with EC50 of 8.00 ± 0.86 and 6.92 ± 1.02 µM, respectively. Compound 4 also displayed significant inhibitory effect of NO production with EC50 value of 8.82 ± 0.30 µM. Based on the established compounds library, structure-activity relationship analysis of phthalides was explored to provide insights into the drug development of vasodilators and anti-flammatory.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Benzofuranos
/
Raíces de Plantas
/
Ligusticum
/
Fitoquímicos
Límite:
Animals
País/Región como asunto:
Asia
Idioma:
En
Revista:
Fitoterapia
Año:
2024
Tipo del documento:
Article