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Embryonic exposures to cadmium and PAHs cause long-term and interacting neurobehavioral effects in zebrafish.
Stickler, Alexandra; Hawkey, Andrew B; Gondal, Anas; Natarajan, Sarabesh; Mead, Mikayla; Levin, Edward D.
Afiliación
  • Stickler A; Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA.
  • Hawkey AB; Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA; Department of Biomedical Sciences, Midwestern University, Downers Grove, IL 60515, USA.
  • Gondal A; Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA.
  • Natarajan S; Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA.
  • Mead M; Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA.
  • Levin ED; Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA. Electronic address: edlevin@duke.edu.
Neurotoxicol Teratol ; 102: 107339, 2024.
Article en En | MEDLINE | ID: mdl-38452988
ABSTRACT
Developmental exposure to either polycyclic aromatic hydrocarbons (PAHs) or heavy metals has been shown to cause persisting and overlapping neurobehavioral effects in animal models. However, interactions between these compounds have not been well characterized, despite their co-occurrence in a variety of environmental media. In two companion studies, we examined the effects of developmental exposure to cadmium (Cd) with or without co-exposure to prototypic PAHs benzo[a]pyrene (BaP, Exp. 1) or fluoranthene (FA, Exp. 2) using a developing zebrafish model. Zebrafish embryos were exposed to Cd (0-0.3 µM), BaP (0-3 µM), FA (0-1.0 µM), or binary Cd-PAH mixtures from 5 to 122 h post fertilization (hpf). In Exp. 1, Cd and BaP produced independent effects on an array of outcomes and interacting effects on specific outcomes. Notably, Cd-induced deficits in dark-induced locomotor stimulation were attenuated by BaP co-exposure in the larval motility test and BaP-induced hyperactivity was attenuated by Cd co-exposure in the adolescent novel tank test. Likewise, in Exp. 2, Cd and FA produced both independent and interacting effects. FA-induced increases on adult post-tap activity in the tap startle test were attenuated by co-exposure with Cd. On the predator avoidance test, FA- and 0.3 µM Cd-induced hyperactivity effects were attenuated by their co-exposure. Taken together, these data indicate that while the effects of Cd and these representative PAHs on zebrafish behavior were largely independent of one another, binary mixtures can produce sub-additive effects for some neurobehavioral outcomes and at certain ages. This research emphasizes the need for detailed risk assessments of mixtures containing contaminants of differing classes, and for clarity on the mechanisms which allow cross-class toxicant interactions to occur.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hidrocarburos Policíclicos Aromáticos Límite: Animals Idioma: En Revista: Neurotoxicol Teratol Asunto de la revista: NEUROLOGIA / TOXICOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hidrocarburos Policíclicos Aromáticos Límite: Animals Idioma: En Revista: Neurotoxicol Teratol Asunto de la revista: NEUROLOGIA / TOXICOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos
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