Novel MED15::ATF1 fusion in a pediatric melanoma with spitzoid features and aggressive presentation.
Genes Chromosomes Cancer
; 63(3): e23230, 2024 03.
Article
en En
| MEDLINE
| ID: mdl-38459940
ABSTRACT
Childhood melanoma is a rare and biologically heterogeneous pediatric malignancy. The differential diagnosis of pediatric melanoma is usually broad, including a wide variety of spindle cell or epithelioid neoplasms. Different molecular alterations affecting the MAPK and PI3K/AKT/mTOR pathways, tumor suppressor genes, and telomerase reactivation have been implicated in melanoma tumorigenesis and progression. Here, we report a novel MED15ATF1 fusion in a pediatric melanoma with spitzoid features and an aggressive clinical course.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Pirroles
/
Neoplasias Cutáneas
/
Proteínas de Fusión Oncogénica
/
Nevo de Células Epitelioides y Fusiformes
/
Glicina
/
Melanoma
Límite:
Child
/
Humans
Idioma:
En
Revista:
Genes Chromosomes Cancer
Asunto de la revista:
BIOLOGIA MOLECULAR
/
NEOPLASIAS
Año:
2024
Tipo del documento:
Article
País de afiliación:
Estados Unidos