Teratogenicity of zonisamide and other little-used antiseizure medications.
Seizure
; 117: 198-201, 2024 Apr.
Article
en En
| MEDLINE
| ID: mdl-38460459
ABSTRACT
PURPOSE:
To investigate the risk of teratogenesis occurring in relation to intrauterine exposure to infrequently used antiseizure medications in Australia.METHODS:
Analysis of data contained in the Raoul Wallenberg Australian Pregnancy Register of Antiepileptic Drugs.RESULTS:
There was statistically significant evidence that zonisamide, but not any other of nine infrequently used antiseizure medications in Australia, was associated with a risk of teratogenesis related to the maternal dose of the drug taken in at least the earlier half of pregnancy.CONCLUSIONS:
The teratogenesis associated with zonisamide, like that associated with topiramate and possibly acetazolamide, may be an expression of a class effect shared among sulphonamide-derived carbonic anhydrase inhibitors that possess anti-seizure activity.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Zonisamida
/
Anticonvulsivantes
Límite:
Adult
/
Female
/
Humans
/
Pregnancy
País/Región como asunto:
Oceania
Idioma:
En
Revista:
Seizure
Asunto de la revista:
NEUROLOGIA
Año:
2024
Tipo del documento:
Article