The RNA tether model for human chromosomal translocation fragile zones.
Trends Biochem Sci
; 49(5): 391-400, 2024 May.
Article
en En
| MEDLINE
| ID: mdl-38490833
ABSTRACT
One of the two chromosomal breakage events in recurring translocations in B cell neoplasms is often due to the recombination-activating gene complex (RAG complex) releasing DNA ends before end joining. The other break occurs in a fragile zone of 20-600 bp in a non-antigen receptor gene locus, with a more complex and intriguing set of mechanistic factors underlying such narrow fragile zones. These factors include activation-induced deaminase (AID), which acts only at regions of single-stranded DNA (ssDNA). Recent work leads to a model involving the tethering of AID to the nascent RNA as it emerges from the RNA polymerase. This mechanism may have relevance in class switch recombination (CSR) and somatic hypermutation (SHM), as well as broader relevance for other DNA enzymes.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Translocación Genética
/
ARN
Límite:
Humans
Idioma:
En
Revista:
Trends Biochem Sci
Año:
2024
Tipo del documento:
Article
País de afiliación:
China