Tracing the Diverse Paths of One-Carbon Metabolism in Cancer and Beyond.
Cold Spring Harb Perspect Med
; 14(9)2024 Sep 03.
Article
en En
| MEDLINE
| ID: mdl-38503499
ABSTRACT
One-carbon (1C) metabolism is a network of biochemical reactions distributed across organelles that delivers folate-activated 1C units to support macromolecule synthesis, methylation, and reductive homeostasis. Fluxes through these pathways are up-regulated in highly proliferative cancer cells, and anti-folates, which target enzymes within the 1C pathway, have long been used in the treatment of cancer. In this work, we review fundamental aspects of 1C metabolism and place it in context with other biosynthetic and redox pathways, such that 1C metabolism acts to bridge pathways across compartments. We further discuss the importance of stable-isotope-tracing techniques combined with mass spectrometry analysis to study 1C metabolism and conclude by highlighting therapeutic approaches that could exploit cancer cells' dependency on 1C metabolism.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Carbono
/
Neoplasias
Límite:
Humans
Idioma:
En
Revista:
Cold Spring Harb Perspect Med
Año:
2024
Tipo del documento:
Article
País de afiliación:
Estados Unidos