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Increased di-(2-ethylhexyl) phthalate exposure poses a differential risk for adult asthma clusters.
Hsu, Yuan-Ting; Wu, Chao-Chien; Wang, Chin-Chou; Sheu, Chau-Chyun; Yang, Yi-Hsin; Cheng, Ming-Yen; Lai, Ruay-Sheng; Leung, Sum-Yee; Lin, Chi-Cheng; Wei, Yu-Feng; Lai, Yung-Fa; Cheng, Meng-Hsuan; Chen, Huang-Chi; Yang, Chih-Jen; Wang, Chien-Jen; Liu, Huei-Ju; Chen, Hua-Ling; Hung, Chih-Hsing; Lee, Chon-Lin; Huang, Ming-Shyan; Huang, Shau-Ku.
Afiliación
  • Hsu YT; National Institute of Environmental Health Sciences, National Health Research Institutes, No.35, Keyan Road, Zhunan, Miaoli County, 35053, Taiwan.
  • Wu CC; National Center for Geriatrics and Welfare Research, National Health Research Institutes, Miaoli, Taiwan.
  • Wang CC; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
  • Sheu CC; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
  • Yang YH; Department of Public Health, Kaohsiung Medical University, Kaohsiung, Taiwan.
  • Cheng MY; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
  • Lai RS; Department of Internal Medicine, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
  • Leung SY; National Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan.
  • Lin CC; Department of Mathematics, Hong Kong Baptist University, Hong Kong, China.
  • Wei YF; Division of Chest Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
  • Lai YF; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
  • Cheng MH; Chest Division, Department of Internal Medicine, Antai Medical Care Cooperation Antai Tian-Sheng Memorial Hospital, Ping-Tung, Taiwan.
  • Chen HC; Department of Internal Medicine, E-Da Cancer Hospital, I-Shou University, Kaohsiung, Taiwan.
  • Yang CJ; Division of Chest Medicine, Department of Internal Medicine, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan.
  • Wang CJ; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
  • Liu HJ; Department of Respiratory Therapy, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
  • Chen HL; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
  • Hung CH; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
  • Lee CL; National Institute of Environmental Health Sciences, National Health Research Institutes, No.35, Keyan Road, Zhunan, Miaoli County, 35053, Taiwan.
  • Huang MS; National Institute of Environmental Health Sciences, National Health Research Institutes, No.35, Keyan Road, Zhunan, Miaoli County, 35053, Taiwan.
  • Huang SK; National Institute of Environmental Health Sciences, National Health Research Institutes, No.35, Keyan Road, Zhunan, Miaoli County, 35053, Taiwan.
Respir Res ; 25(1): 139, 2024 Mar 23.
Article en En | MEDLINE | ID: mdl-38521900
ABSTRACT

BACKGROUND:

DEHP, a common plasticizer known for its hormone-disrupting properties, has been associated with asthma. However, a significant proportion of adult asthma cases are "non-atopic", lacking a clear etiology.

METHODS:

In a case-control study conducted between 2011 and 2015, 365 individuals with current asthma and 235 healthy controls from Kaohsiung City were enrolled. The control group comprised individuals without asthma, Type 2 Diabetes Mellitus (T2DM), hypertension, or other respiratory/allergic conditions. The study leveraged asthma clusters (Clusters A to F) established in a prior investigation. Analysis involved the examination of urinary DEHP metabolites (MEHP and MEHHP), along with the assessment of oxidative stress, sphingolipid metabolites, and inflammatory biomarkers. Statistical analyses encompassed Spearman's rank correlation coefficients, multiple logistic regression, and multinomial logistic regression.

RESULTS:

Asthma clusters (E, D, C, F, A) exhibited significantly higher ORs of MEHHP exposures compared to the control group. When considering asthma-related comorbidities (T2DM, hypertension, or both), patients without comorbidities demonstrated significantly higher ORs of the sum of primary and secondary metabolites (MEHP + MEHHP) and MEHHP compared to those with asthma comorbidities. A consistent positive correlation between urinary HEL and DEHP metabolites was observed, but a consistent negative correlation between DEHP metabolites and selected cytokines was identified.

CONCLUSION:

The current study reveals a heightened risk of MEHHP and MEHP + MEHHP exposure in specific asthma subgroups, emphasizing its complex relationship with asthma. The observed negative correlation with cytokines suggests a new avenue for research, warranting robust evidence from epidemiological and animal studies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 2_ODS3 Problema de salud: 2_quimicos_contaminacion Asunto principal: Ácidos Ftálicos / Asma / Diabetes Mellitus Tipo 2 / Dietilhexil Ftalato / Hipertensión Límite: Adult / Animals / Humans Idioma: En Revista: Respir Res Año: 2024 Tipo del documento: Article País de afiliación: Taiwán

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 2_ODS3 Problema de salud: 2_quimicos_contaminacion Asunto principal: Ácidos Ftálicos / Asma / Diabetes Mellitus Tipo 2 / Dietilhexil Ftalato / Hipertensión Límite: Adult / Animals / Humans Idioma: En Revista: Respir Res Año: 2024 Tipo del documento: Article País de afiliación: Taiwán
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